Skip to main content
  • Research article
  • Open access
  • Published:

Head of bed elevation to relieve gastroesophageal reflux symptoms: a systematic review

Abstract

Background

Overuse of proton pump inhibitors (PPIs) – frequently used for relieving symptoms of gastroesophageal reflux disease (GORD) – raises long-term safety concerns, warranting evidence-based non-drug interventions. We conducted a systematic review to evaluate the effect of head-of-bed elevation on relieving symptoms of GORD in adults.

Methods

We included controlled trials comparing the effect of head-of-bed elevation interventions to control in adults with GORD. Two independent reviewers screened articles, extracted data, and assessed quality of included studies. Primary outcomes were changes in GORD symptoms and use of PPIs.

Results

We screened 1206 records; and included five trials (four cross-over and one factorial) comprising 228 patients. All five included trials were judged to be at high-risk of performance bias and four of selection bias. Of five included trials, two used ‘bed blocks’ under the bed legs; one used ‘sleeping on a wedge’ pillow, and two used both. High heterogeneity in outcome measures and reported outcomes data precluded meta-analyses. The four studies that reported on GORD symptoms found an improvement among participants in the head-of-bed elevation; a high-quality crossover trial showed a clinical important reduction in symptom scores at 6 weeks (risk ratio of 2.1; 95% CI 1.2 to 3.6). These results are supported by the observed improvement in physiological intra-oesophageal pH measurements.

Conclusions

Methodological and reporting limitations in available literature preclude definitive recommendations. However, head-of-bed elevation could be still considered as a cheap and safe alternative to drug interventions with unfavourable safety profiles.

Protocol registration

Open Science Framework: http://osf.io/2hz3j

Peer Review reports

Background

Proton pump inhibitors (PPIs) are among the most commonly prescribed medications worldwide [1]. PPIs are usually prescribed to treat common upper gastrointestinal symptoms often diagnosed as Gastroesophageal Reflux Disease, GORD (i.e. also known as GERD or reflux disease) [2]. While PPIs are effective at controlling these symptoms, there is evidence of great variation in prescribing rates [3], and widespread overuse (e.g. with estimates that between one-quarter and two-thirds of patients may be taking them inappropriately) [1, 4,5,6]. Long term use of PPIs has been linked to a potential increased risk of fractures [7, 8]; pneumonia [9]; and Clostridium difficile infection [10]. Many deprescribing initiatives are underway to reduce the use of PPIs [1, 11]. Against this backdrop of concern about widespread overuse, patient harm and waste, it is timely to investigate the evidence supporting non-drug interventions for the symptoms of GORD [12, 13].

Gastrointestinal symptoms such as heartburn, dyspepsia, and regurgitation are common - one-in-five adults report one of these symptoms at some point in their lives [14]; and they are a very common reason for primary care consultations [15]. Although these symptoms are highly prevalent and can be mild or transient, adults experiencing these symptoms are often diagnosed with GORD. Guidelines recommend a stepwise approach for managing GORD symptoms, beginning with non-drug interventions including lifestyle modifications (e.g. weight loss, smoking cessation, and avoiding late or evening meals), and progressing to drug and surgical interventions when needed [2, 16]. However, the widespread use of drug interventions such as PPIs has rendered non-drug interventions underused and unfashionable, and its full potential as an effective addition or alternative to drug interventions has been under-researched and under-utilised [17].

One promising, easy-to-adopt, non-drug intervention is elevating the head of the bed, which may also be used to avoid, or to lower the dose required of PPIs [12]. A potential mechanism of action is by reducing the oesophageal exposure to stomach acid and increasing the clearance of acid from the oesophagus [18]. Trials have been conducted to evaluate this simple intervention [19, 20], however, we are unaware of any recent high quality systematic review summarizing evidence to inform practice. The aim of this study was to do a systematic review of controlled trials that evaluated the effect of head-of-bed elevation or positioning on relieving GORD symptoms among adults.

Methods

Design

This systematic review is reported following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement [21]. and the review protocol was developed prospectively and registered on the Open Science Framework (osf.io/2hz3j).

Eligibility criteria

Participants

We included studies of adults with symptoms suggestive of GORD (of any severity and as diagnosed in each study).

Interventions

We included studies evaluating change of the head-of-bed position interventions including (i) head-of-bed elevation (either by sleeping on a wedge pillow – ‘sleeping on a wedge’ – or raising the legs of the head of the bed by blocks - ‘bed blocks’); (ii) left lateral sleep position; (iii) or both. Studies evaluating interventions of interest together with co-interventions (e.g. PPIs) were included, as long as the effect of the intervention of interest could be isolated (e.g. head-of-bed elevation plus PPIs vs PPIs alone).

Comparators

We included studies where the comparator was control (i.e. no change to head-of-bed elevation e.g. flat position) or right lateral sleep position.

Outcomes

Primary outcomes were changes in GORD symptoms and use of PPIs. Secondary outcomes included physiological measurements of intra-oesophageal pH (e.g. acid exposure/reflux episodes), disease progression, and adverse events.

Study design

We included randomized and non-randomized controlled trials (RCTs and non-RCTs). We excluded before-after studies with no control group, observational studies, and review articles. We included publications available as abstract only (e.g. conference abstract) only if they reported adequate information required for inclusion.

Search strategies to identify studies

One of the authors, a senior information specialist (JC), searched PubMed, Embase, Cochrane CENTRAL and CINAHL (from inception until 23 June 2020). The search string was designed for PubMed and translated for use in other databases using the Polyglot Search Translator [22]. The complete search strings for all databases are provided in Appendix 1. We also searched clinicaltrials.gov and World Health Organization’s International Clinical Trials Registry Platform (via the Cochrane Library on 23 June 2020) for any relevant registered ongoing or unpublished trials. We supplemented our database searches with a forwards and backwards citation search of all included studies in Scopus database (on 25 June 2020). No restrictions by language or publication date were imposed.

Study selection and screening

Two review authors (LA, RM) independently screened the titles and abstracts for inclusion against inclusion criteria; one author (JC) retrieved full texts, and two authors (LA, RM) screened the full texts for inclusion. Any disagreements were resolved by discussion, or referred to a third author (AD, CDM).

Data extraction and risk of bias assessment

Two review authors (LA, RM) independently extracted data into a prespecified, pilot-tested data extraction form – including the following data on study characteristics; participants; interventions; comparisons; and outcomes.

Two review authors (LA, RM) independently assessed the risk of bias for each included study using the Cochrane Collaboration’s tool for assessing risk of bias [23]. Any disagreements were resolved by discussion or by referring to a third author (AD or CDM).

Data synthesis

We could not undertake meta-analyses because it was not possible or appropriate (i.e. no sufficient comparable data measuring the same outcome). Therefore, we synthesized the results narratively, reporting the results for each outcome separately – following the Synthesis without meta-analysis (SWiM) in systematic reviews guidance [24]. For continuous outcomes, we used mean difference (with 95% CIs) or standardized mean difference, as appropriate. For dichotomous outcomes, we used risk ratios (with 95% CIs) for results reporting the number of people with an event, as appropriate.

Results

We identified 1256 records through database searching and 356 through forward-backward citation analysis for a total of 1206 records to screen after deduplication. We excluded 1181 records after screening titles and abstracts and obtained 25 records for full-text screening. We excluded 20 full-text articles with reasons for exclusion recorded. (Fig. 1) We also screened 36 clinical trial registries and found one relevant trial that we already identified in database searches. We included five studies in the narrative synthesis.

Fig. 1
figure 1

PRISMA flow diagram of included articles

Characteristics of included studies

Of all the five included randomised controlled trials, two were conducted in the United Kingdom [25, 26], with the others in the United States [27], Taiwan [28], and Columbia [29] (Table 1). Three studies were published in the 1970s and 1980s [25,26,27], with the two most recent published in 2019 and 2020 [28, 29]. All studies were small, with total number of participants ranging from 14 to 71, and were of short-term duration, with the longest intervention being for 6 weeks [26, 29]. Four studies were cross-over trials [25, 27,28,29] and one was a factorial RCT [26]. All trials had participants with gastroesophageal reflux symptoms, with one trial conducted among participants who had previously had oesophageal cancer and undergone esophagectomy and gastric tube reconstruction [28]. All included studies were reported in English except for one reported in Spanish, which was also reported in English in clinicaltrials.gov (NCT02706938) [29].

Table 1 Characteristics of included studies (n = 5)

In terms of intervention details (i.e. how elevation was achieved), two trials used ‘bed blocks’ (i.e. 20 cm blocks under the legs of the head of the bed) [26, 29], one trial used ‘sleeping on a wedge’ (i.e. sleeping on a 20 cm wedge-shaped pillow) [28], and two trials used both interventions i.e. 20-28 cm ‘bed blocks’ and ‘sleeping on a wedge’ (as two separate intervention arms) [25, 27]. None of the included studies evaluated the left lateral sleep position as an intervention.

Risk of bias assessment

All five included studies were judged to be at high risk in two or more of the domains of risk of bias. All five studies were judged to be at high risk of performance bias (either blinding of patients and personnel or outcome assessors), and four at high or unclear risk for selection bias (either random sequence generation or allocation concealment) (Fig. 2).

Fig. 2
figure 2

Risk of bias assessment in included studies both in individual studies and domains (left) and in summary (right)

Main findings

Heterogeneity, especially of outcome measures and the reporting of outcome data, precluded meta-analyses of the primary and secondary outcomes. Therefore, we reported the results narratively grouped for each outcome (Table 2).

Table 2 Main results reported in included studies (n = 5)

Gastroesophageal reflux symptoms

All the four (of the five included) studies that we identified evaluating the impact of head of bed elevation on patient-reported gastroesophageal reflux symptoms found an improvement among participants in the head-of-bed elevation intervention arm [25, 26, 28, 29].

A crossover randomized trial analysed the change in GORD symptoms among 39 participants (out of the 65 enrolled participants) at 6 weeks using a 6-point scale, the Reflux Disease Questionnaire Score, with a higher score meaning a worse outcome and a change of ≥0.6 points considered clinically meaningful [29]. The trial found that participants in the head-of-bed elevation group were more likely to report a clinically meaningful change of ≥10% in their symptom scores at 6 weeks compared to the participants in the control group (27 [69%] versus 13 [33%], risk ratio of 2.1; 95% CI 1.2 to 3.6); with a mean difference in change scores of − 1.3, 95% CI − 2.0 to − 0.6).

A crossover trial of 63 participants [25], evaluating the effect of head-of-bed elevation using ‘bed blocks’ or ‘sleeping on a wedge’, found a reduction in the number of reflux symptoms (i.e. heartburn or acid regurgitation) reported during the intervention (i.e. half-night) in the head-of-bed elevation arm (mean difference in ‘bed blocks’ -1, 95% CI − 2.2 to − 0.1; and ‘sleeping on a wedge’ -1, 95% CI − 1.9 to − 0.01) compared to the control group.

A factorial RCT [26], evaluating the effect of ranitidine and head-of-bed elevation among 71 participants, found that participants in the head-of-bed elevation group were more likely to report an overall improvement in their symptoms at 6 weeks compared to the control group (72% [23 of 32] vs. 55% [17 of 31]; unadjusted odds ratio 2.1, 95% CI 0.7 to 6.0; odds ratio adjusted for ranitidine use 3.1, p < 0.005). It also found a reduction in the reported scores, measured on a 4-point-scale, of gastroesophageal reflux and retrosternal pain symptom in the head-of-bed elevation group compared to the control group. There was no statistically significant difference in overall improvement of symptoms reported by adults receiving the head-of-bed elevation only compared to adults receiving ranitidine only (59% [10 of 17] head-of-bed elevation only vs. 77% [13 of 17] ranitidine only; RR 0.8, 95% CI 0.5 to 1.2).

Another crossover trial measured the change in GORD symptoms among 14 post-esophagectomy participants at 2 weeks on a 30-point score, the modified Dysfunction after Upper Gastrointestinal Surgery scale, with a higher score meaning a worse outcome [28]. It found a statistically significant improvement in GORD symptoms in the head-of-bed elevation group compared to the control group (mean difference in change scores − 5.1, 95% CI − 7.6 to − 2.6).

Intra-oesophageal pH measurement

We identified two trials evaluating the impact of head-of-bed elevation using ‘bed blocks’ or ‘sleeping on a wedge’ on the intra-oesophageal pH measurement (i.e. reported as the number of reflux episodes; percent of total time pH remained < 4; and acid clearance time) [25, 27].

A cross-over RCT of 15 participants [27], found a statistically significant reduction in acid exposure (defined as percent of total time intra-oesophageal pH remained ≤4) in both groups (mean % of total time: ‘sleeping on a wedge’ 15, 95% CI 3 to 26; ‘bed blocks’ 15, 95% CI 0 to 31; control 21, 95% CI 10 to 33); but not in the number of reflux episodes (defined as the total number of occasions of intra-oesophageal drop to < 4) and acid clearance time (defined as the total time that intra-oesophageal pH remained < 4 by the number of reflux episodes) in any of the two groups compared to the control group.

In addition to measuring GORD symptoms [25], participants in the ‘bed blocks’ arm in a cross-over study had statistically significant reductions in acid exposure (mean difference in % of total time that intra-oesophageal pH remained < 4, − 7.3, 95% CI − 13.9 to − 0.7) and reflux episodes (mean difference in number of drops in intra-oesophageal pH by two per participants, − 2.5, 95% CI − 4.2 to − 0.8) compared to participants in the control arm. But there were no statistically significant reductions neither in acid exposure (mean difference in % of total time, 1.2, 95% CI − 3.9 to 6.3) nor in reflux episodes (mean difference in number of episodes per participants, − 0.6, 95% CI − 2.3 to 1.1) among participants in the ‘sleeping on a wedge’ compared to the control.

Patient preferences

We identified two studies that measured patient preferences for head-of-bed elevation using ‘bed blocks’ or ‘sleeping on a wedge’. [27, 29] In a crossover trial [29], 36 of the 57 participants (63, 95% CI 51 to 76%) preferred the head-of-bed elevation to control intervention. Of the 15 participants included in another trial [27], 9 (60%) preferred ‘bed blocks’; 5 (33%) preferred ‘sleeping on a wedge’; and one (7%) preferred neither.

Adverse events

We identified two trials reporting adverse events associated with the intervention [26, 29]. A 2020 crossover RCT found that 39 of 63 participants (62%) in head-of-bed elevation group reported largely minor adverse events at 14 weeks compared to no one in the control group (24 bed-related e.g. bed slipping and unsteadiness; and 15 others e.g. varicose vain pain, musculoskeletal pain, and sexual activity interference) [29]. A factorial RCT found that two of 32 participants in the head-of-bed elevation group reported adverse events (one bed slipping and one sexual activity interference); both resolved and neither discontinued the intervention [26].

Discussion

Summary

We found five eligible controlled trials, evaluating the effect of head-of-bed elevation on GORD. Overall, the results suggest that head-of-bed elevation may have a beneficial effect on relieving gastroesophageal reflux symptoms. These results are supported by the observed improvement in physiological intra-oesophageal pH measurements. However, methodological and reporting issues limit the conclusions that can be drawn on the impact of head-of-bed elevation.

Strengths and limitations

There are several limitations to our findings. The key limitation to our systematic review was the very small pool of existing evidence, and the poor quality and inadequate reporting of included trials. Most trials had small sample sizes and were of limited duration – none longer than 6 weeks – with considerable variations in the outcome measures, which precluded meta-analyses of the results from included studies. However, these are frequently reported challenges in trials evaluating non-drug interventions [30, 31]. The strengths of this review include its exhaustive search of multiple databases; inclusion of non-English language trials (i.e. minimising risk of language bias); rigorous quality assessment; and adherence to the Cochrane methodological standards [32] and PRISMA reporting guidance [33].

Comparison with existing literature

A 2006 systematic review of lifestyles measures for gastroesophageal reflux [12] identified full reports from just two trials of head-of-bed elevation [25, 27] – both included in our review – which showed improvements in reflux symptoms and physiological intra-oesophageal pH measures. A 2016 systematic review published in Chinese, with a focus on patients experiencing reflux after treatment for oesophageal cancer, similarly concluded that head-of-bed elevation can improve reflux symptoms [34]. Two more recent studies from 2019 [28] and 2020 [29] were included in our systematic review.

Implications for research and/or practice

The overuse of PPIs for gastroesophageal symptoms is a health problem, and a clinical challenge for clinicians globally. The findings of this review have confirmed that elevating the head of the bed is a cheap, easy-to-implement, relatively safe and promising approach. Importantly we did not find evidence of no benefit from this approach, but rather we found low quality evidence of benefit. Given the need to reduce the overuse of unnecessary medicines – with an unfavourable safety profile [35]– clinicians must be able to offer evidence-based non-pharmacological alternatives for treating these extremely common symptoms.

Additional quality randomized controlled trials evaluating the effect of head-of-bed elevation as part of a package of non-drug interventions in primary care settings are warranted. Future trials need to be of rigorous methodological quality with adequate sample size and duration to detect clinically meaningful differences and consistently measure and report patient-relevant outcomes. As de-prescribing and other initiatives targeting PPI overuse continue [1], offering clinicians and the public alternative non-drug approaches becomes critical.

Conclusions

Methodological and reporting limitations in available literature preclude confident conclusions about the effect of head of bed elevation in relieving gastroesophageal symptoms. However, head of bed elevation could be still considered as a cheap, relatively safe, and promising alternative to drug interventions with unfavourable safety profiles.

Availability of data and materials

The datasets used and/or analysed during the current study are available from the corresponding author on reasonable request.

References

  1. Wu J, Dickinson S, Elgebaly Z, Blogg S, Heaney A, Soo Y, et al. Impact of NPS MedicineWise general practitioner education programs and choosing wisely Australia recommendations on prescribing of proton pump inhibitors in Australia. BMC Fam Pract. 2020;21(1):85.

    Article  Google Scholar 

  2. Katz PO, Gerson LB, Vela MF. Guidelines for the diagnosis and management of gastroesophageal reflux disease. Am J Gastroenterol. 2013;108(3):308–28 quiz 29.

    Article  Google Scholar 

  3. The Third Atlas of Healthcare Variation 2018 - 2.3 Proton pump inhibitor medicines dispensing 18-years and over. Australian Commission on Safety and Quality in Health Care and Australian Institute of Health and Welfare (ACSQHC). Sydney; 2018.

  4. Forgacs I, Loganayagam A. Overprescribing proton pump inhibitors. BMJ. 2008;336(7634):2–3.

    Article  Google Scholar 

  5. Batuwitage BT, Kingham JG, Morgan NE, Bartlett RL. Inappropriate prescribing of proton pump inhibitors in primary care. Postgrad Med J. 2007;83(975):66–8.

    Article  Google Scholar 

  6. Heidelbaugh JJ, Goldberg KL, Inadomi JM. Magnitude and economic effect of overuse of antisecretory therapy in the ambulatory care setting. Am J Manag Care. 2010;16(9):e228–34.

    PubMed  Google Scholar 

  7. Poly TN, Islam MM, Yang HC, Wu CC, Li YJ. Proton pump inhibitors and risk of hip fracture: a meta-analysis of observational studies. Osteoporos Int. 2019;30(1):103–14.

    Article  CAS  Google Scholar 

  8. Ngamruengphong S, Leontiadis GI, Radhi S, Dentino A, Nugent K. Proton pump inhibitors and risk of fracture: a systematic review and meta-analysis of observational studies. Am J Gastroenterol. 2011;106(7):1209–18 quiz 19.

    Article  CAS  Google Scholar 

  9. Eom CS, Jeon CY, Lim JW, Cho EG, Park SM, Lee KS. Use of acid-suppressive drugs and risk of pneumonia: a systematic review and meta-analysis. CMAJ. 2011;183(3):310–9.

    Article  Google Scholar 

  10. Trifan A, Stanciu C, Girleanu I, Stoica OC, Singeap AM, Maxim R, et al. Proton pump inhibitors therapy and risk of Clostridium difficile infection: systematic review and meta-analysis. World J Gastroenterol. 2017;23(35):6500–15.

    Article  CAS  Google Scholar 

  11. Farrell B, Pottie K, Thompson W, Boghossian T, Pizzola L, Rashid FJ, et al. Deprescribing proton pump inhibitors: evidence-based clinical practice guideline. Can Fam Physician. 2017;63(5):354–64.

    PubMed  PubMed Central  Google Scholar 

  12. Kaltenbach T, Crockett S, Gerson LB. Are lifestyle measures effective in patients with gastroesophageal reflux disease? An evidence-based approach. Arch Intern Med. 2006;166(9):965–71.

    Article  Google Scholar 

  13. Scarpignato C, Gatta L, Zullo A, Blandizzi C, Group S-A-F, Italian Society of Pharmacology tIAoHG, et al. Effective and safe proton pump inhibitor therapy in acid-related diseases - A position paper addressing benefits and potential harms of acid suppression. BMC Med. 2016;14(1):179.

    Article  Google Scholar 

  14. Eusebi LH, Black CJ, Howden CW, Ford AC. Effectiveness of management strategies for uninvestigated dyspepsia: systematic review and network meta-analysis. BMJ. 2019;367:l6483.

    Article  Google Scholar 

  15. Cooke G, Valenti L, Glasziou P, Britt H. Common general practice presentations and publication frequency. Aust Fam Physician. 2013;42(1–2):65–8.

    PubMed  Google Scholar 

  16. National Institute for Health and Care Excellence (NICE). Gastro-oesophageal reflux disease and dyspepsia in adults: investigation and management. 2019.

    Google Scholar 

  17. Dibley LB, Norton C, Jones R. Non-pharmacological intervention for gastro-oesophageal reflux disease in primary care. Br J Gen Pract. 2010;60(581):e459–65.

    Article  Google Scholar 

  18. Person E, Rife C, Freeman J, Clark A, Castell DO. A novel sleep positioning device reduces Gastroesophageal reflux: a randomized controlled trial. J Clin Gastroenterol. 2015;49(8):655–9.

    Article  Google Scholar 

  19. Singh M, Lee J, Gupta N, Gaddam S, Smith BK, Wani SB, et al. Weight loss can lead to resolution of gastroesophageal reflux disease symptoms: a prospective intervention trial. Obesity (Silver Spring). 2013;21(2):284–90.

    Article  Google Scholar 

  20. Piesman M, Hwang I, Maydonovitch C, Wong RK. Nocturnal reflux episodes following the administration of a standardized meal. Does timing matter? Am J Gastroenterol. 2007;102(10):2128–34.

    Article  Google Scholar 

  21. Liberati A, Altman DG, Tetzlaff J, Mulrow C, Gotzsche PC, Ioannidis JP, et al. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration. BMJ. 2009;339:b2700.

    Article  Google Scholar 

  22. Clark JM, Sanders S, Carter M, Honeyman D, Cleo G, Auld Y, et al. Improving the translation of search strategies using the polyglot search translator: a randomized controlled trial. J Med Libr Assoc. 2020;108(2):195–207.

    Article  Google Scholar 

  23. Higgins JP, Altman DG, Gotzsche PC, Juni P, Moher D, Oxman AD, et al. The Cochrane Collaboration's tool for assessing risk of bias in randomised trials. BMJ. 2011;343:d5928.

    Article  Google Scholar 

  24. Campbell M, McKenzie JE, Sowden A, Katikireddi SV, Brennan SE, Ellis S, et al. Synthesis without meta-analysis (SWiM) in systematic reviews: reporting guideline. BMJ. 2020;368:l6890.

    Article  Google Scholar 

  25. Stanciu C, Bennett JR. Effects of posture on gastro-oesophageal reflux. Digestion. 1977;15(2):104–9.

    Article  CAS  Google Scholar 

  26. Harvey RF, Gordon PC, Hadley N, Long DE, Gill TR, Macpherson RI, et al. Effects of sleeping with the bed-head raised and of ranitidine in patients with severe peptic oesophagitis. Lancet. 1987;2(8569):1200–3.

    Article  CAS  Google Scholar 

  27. Hamilton JW, Boisen RJ, Yamamoto DT, Wagner JL, Reichelderfer M. Sleeping on a wedge diminishes exposure of the esophagus to refluxed acid. Dig Dis Sci. 1988;33(5):518–22.

    Article  CAS  Google Scholar 

  28. Huang HC, Chang YJ, Tseng YL, Fang SY. Effect of Head-of-Bed Elevation on Nocturnal Reflux Symptoms of Esophageal Cancer Patients With Esophagectomy and Reconstruction. Cancer Nurs. 2019. Online ahead of print.

  29. Villamil Morales IM, Gallego Ospina DM, Otero Regino WA. Impact of head of bed elevation in symptoms of patients with gastroesophageal reflux disease: a randomized single-blind study (IBELGA). Gastroenterol Hepatol. 2020;43(6):310–21.

    Article  Google Scholar 

  30. Boutron I, Tubach F, Giraudeau B, Ravaud P. Blinding was judged more difficult to achieve and maintain in nonpharmacologic than pharmacologic trials. J Clin Epidemiol. 2004;57(6):543–50.

    Article  Google Scholar 

  31. Hoffmann TC, Erueti C, Glasziou PP. Poor description of non-pharmacological interventions: analysis of consecutive sample of randomised trials. BMJ. 2013;347:f3755.

    Article  Google Scholar 

  32. Higgins JPTT, J., Chandler J, Cumpston M, Li T, Page MJ, Welch VA. Cochrane Handbook for Systematic Reviews of Interventions; 2019.

    Book  Google Scholar 

  33. Moher D, Liberati A, Tetzlaff J, Altman DG, Group P. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. BMJ. 2009;339:b2535.

    Article  Google Scholar 

  34. Huang HC, Fang SY. A systematic review of the literature related to elevating the head of the bed for patients with Gastroesophageal reflux disease: applications in patients after esophageal Cancer surgery. Hu Li Za Zhi. 2016;63(3):83–93.

    PubMed  Google Scholar 

  35. Safety of Long-Term PPI Use. JAMA. 2017;318(12):1177–8. https://doi.org/10.1001/jama.2017.13272.

Download references

Acknowledgments

We thanks David King, Paul Kuo, Ben Ewald for providing helpful comments and feedback on earlier version of this manuscript.

Funding

No specific funding for this research.

Author information

Authors and Affiliations

Authors

Contributions

LA, RM, AD, CDM designed the study. LA, RM screened the articles. LA, RM extracted data. LA, RM, AMS drafted the original manuscript and all authors revised the paper. The corresponding author attests that all listed authors meet authorship criteria and that no others meeting the criteria have been omitted. LA is the guarantor of the study. The author(s) read and approved the final manuscript.

Corresponding author

Correspondence to Loai Albarqouni.

Ethics declarations

Ethics approval and consent to participate

Not applicable.

Consent for publication

Not applicable.

Competing interests

No support from any organisation for the submitted work; no other relationships or activities that could appear to have influenced the submitted work.

Additional information

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Supplementary Information

Additional file 1: Appendix 1.

Search strategy and databases search string.

Rights and permissions

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Albarqouni, L., Moynihan, R., Clark, J. et al. Head of bed elevation to relieve gastroesophageal reflux symptoms: a systematic review. BMC Fam Pract 22, 24 (2021). https://doi.org/10.1186/s12875-021-01369-0

Download citation

  • Received:

  • Accepted:

  • Published:

  • DOI: https://doi.org/10.1186/s12875-021-01369-0

Keywords