Epley manoeuvre compared with the control for BPPV | |||||
Patient or population: Patients with definite diagnosis of BPPV Setting: Primary-care clinic Intervention: Epley manoeuvre Comparison: Sham manoeuvre or no treatment or drug | |||||
Outcomes | Anticipated absolute effects * (95% CI) | Relative effect (95% CI) | № of participants (studies) | Certainty of the evidence (GRADE) | |
Risk with Control | Risk with Epley manoeuvre | ||||
Disappearance of subjective symptoms (vertigo) | 238 events per 1,000 participants | 496 events per 1,000 participants (380 to 611) | RR 3.14 (1.96–5.02) | 309 (3 RCTs) | ⨁⨁◯◯ Lowa,b |
Negative findings (DH test) | 406 events per 1,000 participants | 592 events per 1,000 participants (292 to 1,000) | RR 1.46 (0.72–2.97) | 206 (2 RCTs) | ⨁◯◯◯ Very lowa,c |
All adverse events | not pooled | not pooled | - | - | - |
Disappearance of objective symptoms (nystagmus) | 785 events per 1,000 participants | 934 events per 1,000 participants (808 to 1000) | RR 1.19 (1.03–1.38) | 127 (1 RCT) | ⨁⨁◯◯ Lowc |
Dizziness Handicap Inventory | The mean is 0 | MD 2 lower (5.51 lower to 1.51 higher) | - | 134 (1 RCT) | ⨁⨁◯◯ Lowa,b |
*The risk in the intervention group (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI). DH test: Dix–Hallpike test; BPPV: benign paroxysmal positional vertigo; CI: confidence interval; MD: mean difference; RR: risk ratio; SMD: standardised mean difference; | |||||
GRADE Working group grades of evidence High certainty: we are very confident that the true effect lies close to that of the estimate of the effect. Moderate certainty: we are moderately confident in the effect estimate: the true effect is likely to be close to the estimate of the effect, but there is a possibility that it is substantially different. Low certainty: our confidence in the effect estimate is limited: the true effect may be substantially different from the estimate of the effect. Very low certainty: we have very little confidence in the effect estimate: the true effect is likely to be substantially different from the estimate of effect. | |||||
Explanations a. Downgraded one level for risk of bias b. Downgraded one level for imprecision c. Downgraded two level for imprecision |