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Table 2 Characteristics associated with serological prescription among EM episodes reported between 2011 and 2020, N = 1684

From: Prevalence and factors associated with a prescription of a Lyme borreliosis serology for erythema migrans diagnosis in general practice: a study from the French sentinel network, 2009–2020

 

Prescription of a serological test

 

n in row (%)

Crude OR [95% CI]

p-value

Adjusted OR

[95% CI]

p-value

Patients and episodes characteristics

    

Age, in years

  

0.21

 

0.94

 ≤ 15

26 (16.6)

0.70 [0.37–1.32]

 

0.83 [0.37–1.87]

 

 ]15–35]

56 (23.1)

1.06 [0.63–1.79]

 

0.94 [0.46–1.89]

 

 ]35–50]

70 (21.7)

Ref.

 

Ref.

 

 ]50–65]

127 (24.5)

1.36 [0.88–2.10]

 

1.11 [0.63–1.96]

 

 More than 65

76 (20.9)

1.01 [0.63–1.63]

 

0.95 [0.51–1.77]

 

Gender

  

0.16

 

0.15

 Female

192 (23.2)

Ref.

 

Ref.

 

 Male

155 (21.1)

0.80 [0.58–1.09]

 

0.74 [0.49–1.11]

 

Reported tick bite

  

< 0.001

 

< 0.01

 Yes

196 (19.0)

Ref.

 

Ref.

 

 No

108 (27.1)

2.21 [1.52–3.20]

 

1.95 [1.23–3.09]

 

Erythema migrans size

  

< 0.001

 

< 0.001

 < 5 centimeters

49 (13.9)

Ref.

 

Ref.

 

 ≥ 5 centimeters

296 (24.1)

3.04 [1.94–4.74]

 

4.34 [2.33–8.08]

 

Type of EM

  

< 0.001

 

< 0.01

 Single

319 (21.0)

Ref.

 

Ref.

 

 Multiple

30 (42.2)

3.73 [1.91–7.29]

 

3.82 [1.63–8.92]

 

Centrifugal growth

  

0.32

 

0.42

 Yes

278 (20.5)

Ref.

 

Ref.

 

 No

21 (25.0)

1.43 [0.71–2.86]

 

1.41 [0.61–3.26]

 

SGPs characteristics

    

Age, in years

  

0.06

 

0.37

 ≤ 40

58 (17.7)

Ref.

 

Ref.

 

 ]40–50]

90 (24.1)

1.95 [1.02–3.70]

 

1.61 [0.77–3.35]

 

 ]50–60]

123 (25.1)

2.39 [1.26–4.52]

 

0.94 [0.43–2.05]

 

 More than 60

76 (18.9)

1.79 [0.90–3.55]

 

1.32 [0.56–3.11]

 

Gender

  

0.18

 

0.55

 Female

111 (22.4)

Ref.

 

Ref.

 

 Male

244 (22.0)

1.45 [0.84–2.52]

 

0.83 [0.44–1.56]

 

Type of practice

  

0.09

 

0.72

 Individual

136 (23.7)

Ref.

 

Ref.

 

 In groups

180 (20.7)

0.60 [0.33–1.08]

 

0.89 [0.48–1.66]

 

Municipality of practice

 

0.60

 

0.85

 Rural

97 (20.9)

Réf.

 

Réf.

 

 Urban

258 (22.6)

1.16 [0.66–2.05]

 

1.06 [0.56–2.03]

 

Regions by incidence rates1,2

  

0.52

 

0.16

 Low incidence region

139 (27.0)

1.37 [0.77–2.43]

 

1.93 [0.94–3.96]

 

 Moderate incidence region

74 (23.8)

1.34 [0.67–2.70]

 

1.84 [0.81–4.18]

 

 High incidence region

141 (18.2)

Ref.

 

Ref.

 

Number of cases seen by SGPs on a yearly basis

< 0.001

 

< 0.01

 ≤ 1 case

150 (38.5)

5.42 [2.48–11.84]

 

5.28 [1.73–16.11]

 

 ]1–5[

168 (20.6)

2.18 [1.00–4.76]

 

2.19 [0.77–6.20]

 

 ≥ 5 cases

37 (9.3)

Ref.

 

Ref.

 

Year of diagnosis

  

< 0.001

 

< 0.001

 2011–2014

141 (41.2)

4.79 [3.21–7.16]

 

4.80 [2.77–8.33]

 

 2015–2019

214 (16.9)

Ref.

 

Ref.

 
  1. Adjusted odds ratio for all variables in the table; Ref.: reference.
  2. 1Regions of SGP’s practice
  3. 2Low incidence rate: < 50 cases/100 000 ; moderate incidence rate: [50–100[ cases/100 000 ; high incidence rate: ≥ 100 cases/100 000