Table 1 Characteristics at index date
Variable | Reference (eGFR > 60) (n = 157,002) | CKD 3 (n = 13,218) | CKD 4 (n = 823) | CKD 5 (n = 91) |
|---|---|---|---|---|
Female gender | 86,851 (55.3%) | 8455 (64.0%) | 496 (60.3%) | 59 (64.8%) |
Age (years) | 61 (51, 71) | 81 (74, 86) | 83 (76, 88) | 83 (76, 89) |
CVD | 26,945 (17.2%) | 5716 (43.2%) | 475 (57.7%) | 51 (56.0%) |
PAD | 4581 (2.9%) | 1119 (8.5%) | 102 (12.4%) | 9 (9.9%) |
COPD | 6287 (4.0%) | 1052 (8.0%) | 80 (9.7%) | 7 (7.7%) |
HF | 5314 (3.4%) | 2287 (17.3%) | 257 (31.2%) | 23 (25.3%) |
Diabetes | 11,592 (7.4%) | 1158 (8.8%) | 66 (8.0%) | 9 (9.9%) |
Insulin therapy | 2039 (1.3%) | 508 (3.8%) | 53 (6.4%) | 9 (9.9%) |
Non-insulin diabetes therapy | 11,441 (7.3%) | 1237 (9.4%) | 79 (9.6%) | 7 (7.7%) |
Aspirin | 24,912 (15.9%) | 4894 (37.0%) | 346 (42.0%) | 39 (42.9%) |
Clopidogrel | 2436 (1.6%) | 335 (2.5%) | 26 (3.2%) | < 5 |
Statin | 23,718 (15.1%) | 2287 (17.3%) | 133 (16.2%) | 7 (7.7%) |
Diuretics | 36,877 (23.5%) | 7770 (58.8%) | 641 (77.9%) | 66 (72.5%) |
Betablocking agents | 19,398 (12.4%) | 3231 (24.4%) | 226 (27.5%) | 27 (29.7%) |
Calcium antagonists | 20,865 (13.3%) | 2955 (22.4%) | 240 (29.2%) | 28 (30.8%) |
Renin angiotensin system blockers | 37,174 (23.7%) | 4980 (37.7%) | 317 (38.5%) | 27 (29.7%) |
Antihypertensive treatment | 84,134 (53.6%) | 2767 (20.9%) | 102 (12.4%) | 11 (12.1%) |
Total cholesterol (mmol/l) | 5.5 (4.8, 6.2) | 5.4 (4.5, 6.2) | 5.0 (4.1, 6.0) | 5.0 (3.3, 6.3) |
Not measured | 56,462 (36.0%) | 7845 (59.4%) | 600 (72.9%) | 76 (83.5%) |
LDL cholesterol (mmol/l) | 3.3 (2.6, 3.9) | 3.1 (2.4, 3.8) | 2.7 (2.2, 3.7) | 3.2 (1.6, 3.6) |
Not measured | 85,444 (54.4%) | 9933 (75.1%) | 696 (84.6%) | 82 (90.1%) |
Potassium | 4.3 (4.1, 4.5) | 4.4 (4.1, 4.7) | 4.6 (4.3, 5.0) | 4.6 (4.3, 5.0) |
Not measured | 35,005 (22.3%) | 1687 (12.8%) | 76 (9.2%) | 9 (9.9%) |
HbA1c (mmol/mol) | 38.0 (34.0, 45.0) | 41.0 (36.0, 50.0) | 41.0 (36.0, 47.0) | 43.0 (37.0, 50.0) |
Not measured | 110,944 (70.7%) | 9851 (74.5%) | 622 (75.6%) | 62 (68.1%) |
Estimated GFR (ml/min/1.73 m2) | 87.0 (76.0, 98.0) | 47.0 (39.5, 53.0) | 23.0 (19.0, 26.0) | 12.0 (9.0, 13.5) |
Urinary albumin creatine ratio (mg/g) | 10.0 (10.0, 22.0) | 19.0 (10.0, 84.0) | 160.0 (32.5, 590.0) | |
Not measured | 145,826 (92.9%) | 12,595 (95.3%) | 796 (96.7%) |