Table 2 Characteristics of study cohort

Patients

1,294,021

133,279 (100)

65,612 (49.2)

8,974 (6.7)

18,253 (13.7)

25,264 (19.0)

15,176 (11.4)

Age at diagnosis in years

 18–44

694,705 (53.7)

30,139 (22.6)

29,977 (45.7)

N/A

N/A

N/A

162 (1.07)

 45–54

192,397 (14.9)

29,215 (21.9)

11,153 (17.0)

3,025 (33.7)

5,345 (29.3)

5,900 (23.4)

3,792 (25.0)

 55–64

170,122 (13.1)

28,689 (21.6)

9,313 (14.2)

2,492 (27.8)

5,328 (29.2)

7,312 (28.9)

4,244 (28.0)

 65–74

130,085 (10.1)

24,563 (18.4)

7,554 (11.5)

1,913 (21.3)

4,269 (23.4)

7,014 (27.8)

3,813 (25.1)

 75–84

72,814 (5.6)

14,947 (11.2)

5,165 (7.9)

1,127 (12.6)

2,398 (13.1)

3,841 (15.2)

2,416 (15.9)

 85 + 

33,898 (2.6)

5,726 (4.3)

2,450 (3.7)

417 (4.6)

913 (5.0)

1,197 (4.7)

749 (4.9)

Gender

 Male

554,598 (42.9)

59,692 (44.8)

30,513 (46.5)

3,670 (40.9)

8,170 (44.8)

11,124 (44.0)

6,215 (41.0)

 Female

734,789 (56.8)

73,460 (55.1)

35,009 (53.4)

5,297 (59.0)

10,075 (55.2)

14,121 (55.9)

8,958 (59.0)

  (Missing)

4,634 (0.4)

127 (0.1)

90 (0.1)

7 (0.1)

8 (0.04)

19 (0.08)

3 (0.02)

Remoteness

 Metropolitan

1,143,398 (88.4)

116,064 (87.1)

57,253 (87.3)

7,883 (87.8)

15,920 (87.2)

21,690 (85.9)

13,318 (87.8)

 Inner regional

123,801 (9.6)

14,256 (10.7)

7,048 (10.7)

885 (9.9)

1,906 (10.4)

2,840 (11.2)

1,577 (10.4)

 Outer regional

20,024 (1.5)

2,507 (1.9)

1,072 (1.7)

180 (2.0)

373 (2.0)

646 (2.6)

236 (1.6)

 Remote

666 (0.05)

53 (0.04)

22 (0.03)

5 (0.06)

5 (0.03)

14 (0.06)

7 (0.05)

 Very remote

126 (<0.01)

7 (<0.01)

3 (<0.01)

0 (0.0)

1 (<0.01)

2 (<0.01)

1 (<0.01)

  (Missing)

6,006 (0.5)

329 (0.3)

214 (0.3)

21 (0.2)

48 (0.3)

72 (0.3)

37 (0.2)

Socioeconomic disadvantage

 Quintile 1†

122,617 (9.5)

14,685 (11.0)

7,826 (11.9)

900 (10.0)

1,700 (9.3)

2,473 (9.8)

1,786 (11.8)

 Quintile 2

156,170 (12.1)

18,196 (13.7)

9,337 (14.2)

1,052 (11.7)

2,365 (13.0)

3,403 (13.4)

2,039 (13.4)

 Quintile 3

195,170 (15.1)

23,039 (17.3)

11,156 (17.0)

1,520 (17.0)

3,240 (17.7)

4,326 (17.1)

2,797 (18.4)

 Quintile 4

328,456 (25.4)

34,167 (25.6)

16,969 (25.9)

2,198 (24.5)

4,736 (25.9)

6,358 (25.2)

3,906 (25.7)

 Quintile 5

484,662 (37.5)

42,786 (32.1)

20,102 (30.7)

3,283 (36.6)

6,161 (33.8)

8,632 (34.2)

4,608 (30.4)

 (Missing)

6,195 (0.5)

406 (0.3)

222 (0.3)

21 (0.2)

51 (0.3)

72 (0.3)

40 (0.3)

Comorbidity

At least 1 comorbidity

480,951 (37.2)

83,816 (62.9)

36,178 (55.1)

5,679 (63.3)

11,916 (65.3)

17,051 (67.5)

12,992 (85.6)

 Cancer

29,582 (2.3)

6,759 (5.1)

2,401 (3.7)

525 (5.9)

1,193 (6.5)

1,717 (6.8)

923 (6.1)

 Cardiovascular

219,987 (17.0)

43,628 (32.7)

15,150 (23.1)

3,219 (35.9)

7,134 (39.1)

10,656 (42.2)

7,469 (49.2)

 Dementia

8,041 (0.6)

1,188 (0.9)

501 (0.8)

79 (0.9)

191 (1.1)

256 (1.0)

161 (1.1)

 Depression/anxiety

209,727 (16.2)

33,422 (25.1)

16,527 (25.2)

2,264 (25.2)

4,095 (22.4)

5,164 (20.4)

5,372 (35.4)

 Diabetes

75,465 (5.8)

13,939 (10.5)

4,947 (7.5)

926 (10.3)

2,522 (13.8)

3,152 (12.5)

2,392 (15.9)

 Musculoskeletal

101,101 (7.8)

36,475 (27.4)

15,438 (23.5)

1,925 (21.5)

4,300 (23.6)

6,373 (25.2)

8,439 (55.6)

 Obesity

38,475 (3.0)

8,624 (6.5)

3,756 (5.7)

436 (4.9)

991 (5.4)

1,859 (7.4)

1,582 (10.4)

 Respiratory

19,893 (1.5)

4,927 (3.7)

2,050 (3.1)

399 (4.5)

710 (3.9)

859 (3.4)

909 (6.0)

 GP consultations during follow-up, n (% within 1 year of diagnosis)

13,255,803 (42.7)

2,295,769 (40.8)

962,558 (43.9)

142,937 (42.6)

294,971 (42.0)

407,309 (40.7)

487,994 (33.5)

 All-cause GP consultations per patient in 1^st year post diagnosis, median (IQR)

4 (2–8)

7 (4–12)

6 (3–12)

7 (4–12)

7 (4–12)

7 (4–12)

11 (6–17)

 Age at diagnosis in years, mean (SD)

45.0 (18.9)

56.5 (17.0)

49.2 (18.5)

61.9 (12.0)

62.8 (11.8)

64.2 (11.5)

63.9 (11.9)

 Follow-up period in years, median (IQR)

3.2 (1.6–4.6)

2.3 (1.0–3.7)

2.2 (1.0–3.6)

2.1 (0.9–3.5)

2.1 (1.0–3.5)

2.2 (1.0–3.7)

3.2 (1.9–4.2)