Table 3 Changes in symptoms and functioning over time between IPCM (N = 112) and CAU (N = 102)

 Baseline

52.78 + 5.25

52.66 + 5.53

.12 [− 1.34 to 1.57] NS

 3 months

52.03 + 5.79

47.90 + 6.07*

4.13 [2.53 to 5.73] ***

 6 months

51.24 + 6.74

46.87 + 6.24***

4.37 [2.62 to 6.12] ***

 12 months

51.42 + 5.51

45.96 + 6.27***

5.47 [3.87 to 7.06] ***

 Baseline

52.29 + 3.65

52.27 + 4.99

.02 [− 1.21 to 1.17] NS

 3 months

52.12 + 6.49

48.94 + 2.90***

3.18 [1.85 to 4.51] ***

 6 months

51.14 + 3.78

47.98 + 4.19**

3.16 [2.08 to 4.24] ***

 12 months

51.58 + 3.89

46.91 + 2.85***

4.67 [3.76 to 5.58] ***

 Baseline

52.53 + 6.45

52.90 + 6.13

.37 [− 1.33 to 2.07] NS

 3 months

51.72 + 5.97

48.80 + 6.02***

2.92 [− 1.30 to 4.54] **

 6 months

50.75 + 5.46

47.45 + 6.61***

3.30 [1.66 to 4.94] ***

 12 months

51.39 + 5.91

46.76 + 6.52***

4.63 [2.95 to 6.31] ***

 Baseline

52.05 + 9.67

52.34 + 9.73

.29 [− 2.33 to 2.91] NS

 3 months

51.85 + 9.32

49.90 + 9.81*

1.9 [.63 to 4.53] NS

 6 months

51.70 + 10.26

49.68 + 9.45*

2.02 [.64 to 4.68] NS

 12 months

52.35 + 9.47

48.56 + 10.51*

3.79 [1.08 to 6.50] **

 Baseline

47.75 + 5.24

48.06 + 5.52

.31 [− 1.14 to 1.76] NS

 3 months

47.51 + 5.79

51.54 + 6.06**

4.03 [2.43 to 5.63] ***

 6 months

48.67 + 6.74

51.72 + 6.25***

3.06 [1.30 to 4.82] ***

 12 months

49.43 + 5.51

52.63 + 6.28***

5.44 [3.86 to 7.05] ***

 Baseline

47.04 + 3.65

47.42 + 4.57

.04 [−.73 to 1.49] NS

 3 months

46.78 + 6.49

48.90 + 2.95*

2.21 [.74 to 3.50] ***

 6 months

48.12 + 3.78

50.36 + 4.21*

2.24 [1.16 to 3.32] ***

 12 months

48.34 + 3.89

50.67 + 2.91*

2.33 [1.40 to 3.26] ***

 Baseline

47.58 + 9.67

48.12 + 9.74

.54 [−2.08 to 3.16] NS

 3 months

47.71 + 9.33

50.69 + 9.81*

2.98 [.40 to 5.56] ***

 6 months

48.39 + 10.24

51.83 + 9.49*

3.44 [.77 to 6.11] ***

 12 months

47.80 + 10.91

52.36 + 10.45**

4.56 [1.68 to 7.44] ***

 Baseline

47.86 + 6.41

47.05 + 6.17

.81 [−.88 to 2.51] NS

 3 months

49.51 + 5.97

51.48 + 6.03*

2.37 [.75 to 3.99]**

 6 months

49.34 + 5.48

51.39 + 6.61*

2.02 [.37 to 3.67]*

 12 months

49.91 + 5.79

51.84 + 6.53***

1.9 [.26 to 3.60]*

 Baseline

48.70 + 5.09

48.57 + 5.23

.13 [−1.26 to 1.52] NS

 3 months

47.56 + 5.04

51.29 + 5.31*

3.73 [2.33 to 5.13]***

 6 months

49.47 + 5.52

53.38 + 6.10**

3.91 [2.34 to 5.48]***

 12 months

50.19 + 5.98

54.27 + 6.02***

4.01 [2.38 to 5.62]***

 Baseline

48.52 + 8.27

48.59 + 7.76

.07 [− 2.23 to 2.09] NS

 3 months

48.94 + 8.02

49.79 + 7.82*

.85 [− 1.29 to 2.99] NS

 6 months

49.91 + 7.89

52.75 + 7.71**

2.84 [.73 to 4.94]**

 12 months

50.13 + 8.26

53.10 + 8.05***

2.97 [.77 to 5.17]**