Figure 1

In the dark grey text box are verbatim extracts from a citation used as data. These point to a summary of what was extracted from this citation (mid-grey box on right-hand side). In this summary possible context (?C) and mechanisms (?M) are noted. During data extraction this evidence was linked to the concept of volitions, which as we gradually developed a mind-map of the data and its interpretation was linked in turn to ‘interactivity’ in the context of ‘absence of cure’ as we sought to understand success and failure within our synthesis. The line of mid-grey boxes demonstrating these links can be read from left to right or vice versa, mirroring the iterative process between theories and data extraction during the synthesis. Pale grey boxes provide a representation of the rest of the mind-map as it is too detailed to show in its entirety. Further details of the full data extraction and synthesis process are given in the methods section of this paper and text Table 1.