Table 3 Follow-up: Reasons for reverting to the same medication as before the N-of-1 trial

Reasons for reverting in series A

   • Perceived lack of efficacy of paracetamol

   • Deterioration of osteoarthritis

   • Misunderstanding regarding paracetamol dosage

   • Preference of small tablets (diclofenac) over larger ones (paracetamol)

   • Patient found it a waste to throw away the NSAIDs she still had in her possession

Reasons for reverting in series B

   • Dosage of temazepam had not been adjusted after the N-of-1 trials

   • Patient sees no disadvantages in taking temazepam