From: Limitations of diabetes pharmacotherapy: results from the Vermont Diabetes Information System study
Medication Regimen | N | Proportion of population, % | Excellent control (A1C < 7%), % | Mean A1C, % |
---|---|---|---|---|
Categorized by number of medications | ||||
   No diabetes medications | 242 | 25 | 80 | 6.5 |
   Monotherapy | 402 | 40 | 58 | 7.2 |
   2 Drugs | 254 | 25 | 46 | 7.4 |
   3 Drugs | 103 | 10 | 29 | 7.6 |
   4 Drugs | 5 | < 1 | 0 | 9.2 |
Categorized by type of medication | ||||
   Any oral medication | 670 | 67 | 51 | 7.3 |
   Oral medication(s) alone | 578 | 58 | 54 | 7.2 |
   Any insulin therapy | 186 | 19 | 35 | 7.8 |
   Insulin alone | 94 | 9 | 41 | 7.6 |
   Both oral medication and insulin | 92 | 9 | 29 | 7.9 |
Monotherapy regimen detail | ||||
   Sulfonylurea | 123 | 12 | 58 | 7.1 |
   Metformin | 126 | 13 | 66 | 7.1 |
   TZD | 55 | 5 | 67 | 6.8 |
   Insulin | 94 | 9 | 41 | 7.6 |
2-Drug Oral Combination detail | ||||
   Sulfonylurea + Metformin | 103 | 10 | 41 | 7.5 |
   Sulfonylurea + TZD | 49 | 5 | 49 | 7.2 |
   Metformin + TZD | 50 | 5 | 60 | 7.1 |
3 Drug Oral Combination detail | ||||
   Sulfonylurea + Metformin + TZD | 67 | 7 | 35 | 7.4 |
Insulin therapy detail | ||||
   Insulin glargine | 90 | 9 | 30 | 8.0 |
   Any insulin + 1 oral agents | 54 | 5 | 38 | 7.8 |
   Any insulin + 2 oral agents | 23 | 2 | 20 | 7.9 |