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Table 3 Outcomes twelve weeks after randomisation to intervention or standard care

From: An explanatory randomised controlled trial of a nurse-led, consultation-based intervention to support patients with adherence to taking glucose lowering medication for type 2 diabetes

  Intervention arm Standard care arm Intervention effect (95% C.I) P-value
  Baseline Final visit Baseline Final visit   
Primary outcome       
Days correct dose taken (SD) (%)* - 77.4 (26.3)a   69.0 (30.8)b 8.4 (0.2, 16.7) c 0.044
Secondary outcomes       
SF12 Physical (SD) 43.3 (11.2) r 44.6 (11.1) c 45.5 (10.3) r 46.3 (9.0) l -0.7 (-2.7, 1.4) s 0.52
SF12 Mental (SD) 48.0 (10.6) 49.5 (10.4) c 50.0 (9.63) t 52.6 (8.8)l -1.6 (-3.9, 0.6) s 0.15
Diabetes treatment satisfaction (SD) - 30.6 (5.4) c - 31.3 (4.6) f -0.7 (-2.2, 0.7) u 0.32
HbA1c % (SD) 8.34 (1.26) k 8.34 (1.24) k 8.29 (1.23) l 8.21 (1.32) f 0.06 (-0.19, 0.32) m 0.64
HbA1c mmol/l (SD) 67.7 (13.8) 67.7 (13.6) 67.1(13.4) 66.2 (14.4) 0.7 (- 2.1, 3.5)  
Medication-related       
MARS Self report adherence (SD) 23.6 (2.3) d 23.6 (2.6) e 23.6 (2.8) f 24.1 (1.6) g -0.4 (-1.0, 0.2) h 0.20
Satisfaction with communication (median, IQR)**   4 (2,5)   4 (2,5)   0.13
% reporting hypoglycaemia (N)***   1.6% (2)   0,0 (0)   0.52*
  1. Values are mean (SD) unless otherwise stated. Missing values: a = 13, b = 4, c = 17, d = 15, e = 27, f = 8, g = 12, h = 39, k = 16, l = 9, m = 24, r = 1, s = 26, t = 2, u = 25.
  2. * - Estimate of intervention effect adjusted for baseline where available and 95% confidence interval derived from the non-parametric bootstrap percentile method with 50,000 replications. † = In the analysis of the final visit measure adjusting for a baseline that has occasional missing data, the missing indicator method is used. ** p value from Mann–Whitney test., *** p value from Fisher’s exact test. MARS Medication Adherence Report Scale.