Bmc Family Practice Gps' Perspectives of Type 2 Diabetes Patients' Adherence to Treatment: a Qualitative Analysis of Barriers and Solutions

Background: The problem of poor compliance/adherence to prescribed treatments is very complex. Health professionals are rarely being asked how they handle the patient's (poor) therapy compliance/adherence. In this study, we examine explicitly the physicians' expectations of their diabetes patients' compliance/adherence. The objectives of our study were: (1) to elicit problems physicians encounter with type 2 diabetes patients' adherence to treatment recommendations; (2) to search for solutions and (3) to discover escape mechanisms in case of frustration.


Background
Diabetes mellitus type 2 is an important and increasing health problem. In Belgium, the incidence is 231 new cases per 100.000 inhabitants per year [1]. It is frequently not diagnosed until complications appear, and approximately one-third of all people with diabetes may remain undiagnosed. The estimated prevalence of diabetes among adults was 7.4 % in 1995; this is expected to rise to about 9 % in 2025 [2]. To date there is strong evidence that vigorous treatment of diabetes type 2 can decrease the morbidity and mortality of the disease by decreasing its chronic complications [3][4][5][6]. However, poor patient compliance/adherence to these treatment recommendations can reduce therapeutic effects.
Earlier research on compliance/adherence showed that neither the features of a disease, nor the referral process, nor the clinical setting nor the therapeutic regimen seem to influence compliance/adherence [7]. Because of the difficulties in measuring, no estimate of compliance/adherence or non-compliance/non-adherence can be generalized. Poor compliance/adherence is to be expected in 30-50 % of all patients, irrespective of disease, prognosis or setting [8][9][10]. Today, more then 200 different doctor-patient-and encounter-related variables have been studied but none of them is consistently related to compliance or fully predictive. Especially in quantitative studies, little attention has been paid to patients' ideas about medicines and compliance/adherence. However, from qualitative research we know that the most salient influences on compliance/adherence are patients' own beliefs about medications and about medicine in general [7]. Their own knowledge, ideas and experiences, as well as those of family members and friends, have also been shown to correlate with compliance [11].
In order to understand and predict compliance/adherence, the patients' attitude towards disease has been studied since more then twenty years by means of the health belief model [12,13]. Today, new concepts of patient involvement, participation and real partnership are introduced [14]. Therapeutic interactions with patients should not longer be viewed simply as opportunities to reinforce instructions around treatment: rather, they should be seen as a space where the expertise of patients and health professionals can be pooled to arrive at mutually agreed goals [15]. In primary care, patients strongly want a patient centered approach, with communication, partnership and health promotion [16]. Evidence is increasing that involving patients more in consultations can increase compliance/adherence to treatment.
Patients and caregivers interpret signs and signals in a different way [17]. These differences in perspective are not inherently problematic. They frequently become so when patients do not meet the goals and expectations of their health care providers. In caregiver's point of view there is an expectation that when they, as authoritative experts, make recommendations, the patient only has the obligation to carry them out [18]. Furthermore, caregivers are increasingly under pressure from health policy makers or managed care organizations to reduce the costs of complications by rigorously complying with treatment guidelines.
Physicians estimate their patients' compliance/adherence to medications, and base decisions about treatment on these estimates. Misjudgment of patient compliance/ adherence can have adverse consequences, including withholding of therapy or unnecessary changes in therapy. A review of the literature demonstrates that physicians are often inaccurate in estimating patient compliance/adherence with antiretroviral therapy [19]. In the field of diabetes, medical anthropologists evaluated an analytical framework for contrasting patient and provider goals and strategies [20]. This framework was designed to allow examination of how a chronic illness fits into both clinical and life-world contexts. By comparing patients' and providers' goals, strategies and evaluation criteria, a better understanding could be developed of how recommended behavioral changes are understood and applied differentially by each group. Using this approach, certain shared outward semantic similarities (i.e. "control") were found between patients' and providers' perspectives that obscured the presence of deeper differences between those perspectives. The differences had important implications for the long-term enactment of diabetes self-care regimes.
The clinical literature on "non-compliance/non-adherence" tends to problematize only the patient's perspective, treating the provider's perspective as an uncontroversial point of departure. Equal consideration is seldom given to the role of provider perspectives and the broader institutional and economic contexts of illness management [21]. Our work on compliance/adherence focusing on the providers' perspective, illustrates the difficulties Belgian GPs experience in trying to help people with diabetes type 2 being adherent to treatment plans.

Methods
This descriptive qualitative study explores the thoughts and feelings of GPs on patients' compliance/adherence. In five focus groups (FG), GPs were asked how they think their type 2 diabetes patients adhere to life style and dietary advices, medicine taking and management of the disease. We sounded out how GPs cope with conflicts concerning these topics. In our analysis, we tried to explore the barriers to compliance/adherence and possible solutions, GPs experience in diabetes management.
We also explored some coping mechanisms they use to handle the conflict arising when patients do not heed their advices.
The focus group technique used was based on a standardized procedure, described in earlier publications [22][23][24].
After approval of the different local societies for primary care and of the ethics committee of the study centre, all GP members (n = 173) working in the surrounding municipalities of the study centre received a letter with some general information on our project. Afterwards, physicians were phoned to assess their interests in participating and subscription in one of the discussion groups planned. Forty interested physicians could be recruited and five focus group sessions were organized. In compiling the different groups, no distinctions were made on age, gender or number of years in practice in the hope of maximizing interaction and outcome. Interested physicians could make their choice between an afternoon and an evening session. They also could choose between a venue on the university campus or not. If after the five focus groups content saturation was not achieved, additional focus groups were planned.
A previous qualitative study on adherence to treatment recommendations in patients living with diabetes [25] revealed five different themes on the problem of compliance/adherence. Together with the results of a comprehensive review of recent literature on adherence [26], these themes were used to generate five open-ended core questions (table 1) exploring the ideas and thoughts of the participant GPs. The precise formulation of these questions was discussed thoroughly by the research team until mutual agreement and piloted in a first focus group.
A diabetes nurse, well-trained and experienced in conduction focus group discussions, moderated all focus groups, guaranteeing a standardized procedure. She observed that the level of involvement was as non-directive as possible, but meanwhile trying to collect as much data as possible, ensuring that the desired set of topics was covered and encouraging the participation of everyone [27,28].
An observer (JW) gathered information on the non-verbal communication and on the interaction between participants. In this way, special attention could be given in the analysis, to those pronouncements and text fragments where verbal and non-verbal consensus existed. The duration of the discussions was limited to two hours.
At the end of every focus group, there was a debriefing between moderator and observer to discuss the most important themes and possible differences with other focus groups. Since participants of FG 5 added no new information anymore, content saturation was supposed to be reached.
The first focus group served as a pilot. Since no indistinctness with regard to the questioning or other procedures were allocated, and since the results were very similar to the other focus group interviews we decided to keep these first results in the analyzing process. In no focus group, any striking nuisance cases were present.
All focus groups were audio taped and transcribed for content analysis.
Two researchers (JW and EV) independently performed the initial coding. In the case of disagreement, a solution was found by clarifying individually the meaning of a code and discussing until mutual consent was reached. We defined the different themes and performed cross-referencing within the different coding categories, and by text word search in the document or selected sections of it. In doing so, we clarified ideas, discovered further themes, searched for patterns and explored participants' explanatory models.
A first draft with results was sent to all participants for agreement on content and comprehensiveness (response rate 72.5 %). This participant checking leaded to only a few interpretative comments. We added or corrected most of them in the draft after discussion and agreement with the moderator.

Results
Of the 173 GPs contacted, 61 agreed to participate (35.3 %), and 40 GPs (23.1 %) attended the focus groups. Physician and practice characteristics are summarized in table 2.
Content analysis of the text fragments resulted in primary codes, which after an inductive interpretation and categorization process could be structured in three themes (table  3): barriers to patient's compliance/adherence as experienced by the GPs; solutions as used by the GPs to increase their patients' compliance/adherence and coping mechanisms used by the GPs.

Barriers to compliance/adherence
With regard to compliance/adherence, GPs recognized two kinds of patients: "motivated" patients and "not-tobe-motivated" patients. The "good" patients were very motivated, they did their best and they almost meticulously followed their regimens. The "bad" patients were hardly to be motivated, they thought they have everything under control but they were neglectful which was frustrating for the GP.  GPs acknowledged the kind of problems patients have with the treatment regimen and realized that a lifestyle change is not that simple. Yet, they felt the patient's opposition by lots of excuses for preservation of non-healthy habits.
On the other hand, some patients have learned to rely on modern medicine that offers medication for every complaint. To take that medicine is easier and fits better in our way of life than to part with dietary habits linked to the patient's cultural environment.
P. If you feel ill, then you take a pill... anyway, there are drugs for all complaints.
The general practitioner GPs quickly begin to feel powerless once they experience that patients do not attain the EBM treatment goals. This has a negative impact on further promotion of compliance/adherence to proposed regimens. GPs cherish high expectations concerning metabolic results in their diabetes patients, but do not succeed in communicating this to their patients. Few GPs liked to repeat time and again the same messages, they didn't like to "nag" or "tease" as it is mentioned in one of the focus groups, as this simply leads to frustration. For all other diabetes patients, mostly treated in primary care, currently there is no reimbursement for education or self-monitoring of blood glucose. The GP felt that his good relationship with the patient is threatened by this inequality, because others can offer their patients advantages that they as GPs cannot give. In the GPs opinion, this interference in the relationship of trust could hinder the compliance/adherence. The superior position of the free accessible "specialist", who may have another message for the patient, also gave many GPs a bad feeling.
P. Our experience points out that some of these centers take over the care of patients and that we never see those patients again. We still get reports and results of blood tests on a regular base but we do not see the patient any more...
Poor co-operation between intra-mural diabetes centers and the GPs divides the care process between different partners ignoring each other's efforts and responsibilities. Moreover, in the system of fee-for-service the GP often has to go along with the expectations of the patient in order to keep him in his surgery and to protect his income. This made the physician thinks his patients do not appreciate his specific expertise and skills, which again may result in frustration and even anger.

Tailored care
GPs considered that the way in which a consultation is carried out could also stimulate compliance/adherence. Important factors seen as able to increase compliance/ adherence were scheduled consultations and teamwork. It should give the patient a better notion of "care giving" when a structured diabetes consultation model is adopted. This, together with consultation hours by appointment give patients a feeling of more time being spent and of more experience being applied on his/her behalf. GPs thought that standardized education tools and a structured diabetes file could improve compliance/ adherence compared with an "ad hoc" consultation in which the GP only tends to go along with patients' complaints and questions.

Shared care
GPs considered that working in a multi disciplinary team might encourage better compliance/adherence. They believed that dieticians could give more adequate and more varied food advice than they could themselves. When they succeeded in referring the patients to the dietician, the majority of patients were very satisfied, but the first step remained difficult. In this way, GPs tighten a net around the patient, restricting his/her freedom of movement. An indication of this restriction can be found in the explicit request for a more tailored care system. In emphasizing this, doctors may minimize their own responsibility and try to shift the blame to the liberal marginal conditions in which they are functioning.
Physicians also considered that patients take refuge behind different reasons in an argued decision, such as cultural motives (for example dietary tradition), financial problems (lack of reimbursement) and strict personal reasons to avoid compliance/adherence. They viewed the motives of patients as deep-rooted and difficult to modify.

Discussion
Many patients for whom diabetes medication is prescribed are poor compliers with treatment, including both oral medication and insulin [29]. In these exploratory focus groups, we discover barriers and solutions for optimal compliance/adherence in people living with diabetes type 2, seen by Belgian GPs.
From the dynamic discussions in the focus groups, we may conclude that this subject was of substantial concern to GPs. There was a constructive mutual interaction and good co-operation in all five focus groups. Open discussions went along with a positive willingness to participate in the debate.
From the GPs' point of view, an inventory could be made of the different barriers and solutions that matter for compliance/adherence of their diabetes patients. This inventory is far from complete. Besides, it was not the intention of this study to make out an exhaustive list of all kinds of compliance/adherence barriers. In this article, we confine ourselves to the viewpoint on compliance/adherence by diabetes patients, as experienced by the GP.
We learn that GPs take a shot at the patients, complaining their deficient knowledge, the fact they minimize diabetes related problems and their blind confidence in medicine. GPs also blame the health care system in which they feel as inferior doctors in comparison with specialists, widely accessible for patients. Taken together, these externalizing factors seem to lead to a profound defeatism. Where the GP tries to give "good" diabetes care by strictly promoting evidence-based diabetes objectives, the patients' "failing" frustrates him. Besides, they recognize the lack of effective communication tools for making the patient a real partner in their decisions.
Probably, GPs feel inclined to allocate the extent of someone's responsibilities too fast. Perhaps, they take too much personal responsibility and focus too much on evidence based medical treatment options wherefore they are real experts and responsible for. A failing in reaching these treatment goals then is a failing of the doctor-expert himself who is doing the best he can. Lifelong guidance of chronic ill patients as is the case in diabetes, asks for shared responsibilities where going about with the disease (behavioral changes, compliance/adherence attitudes, ...) is the patient's responsibility. New essential skills and attributes for a health care provider to promote behavioral change and risk reduction are skills for assessing readiness for behavioral change, relationship building skills, and skills in considering the patient's attitudes and beliefs about the disease or treatment involved [30]. Motivational interviewing, characterized by its empathic nonconfrontive style, assists movement through the stages of change to the "action" stage where engaging in change behavior begins. It is designed to assist clients (patients) in exploring and resolving ambivalence to increase motivation for change. Physicians can use the model to intervene successfully at all different levels of behavioral change, where patients are helped by the model to take responsibility for changing habits [31].
Lacking these skills of motivational counseling and shared decision making, the best method to promote patient's compliance/adherence is assumed to be using shock tactics. Identical conclusions were found in a Polish study were doctors, when confronted with non-compliance, also applied certain tactics of doubtful effectiveness which might worsen the patient's emotional state or harm his as a person. Valuable techniques of proven efficacy were not used [32].
Tailored and shared care is considered as a possible solution for better compliance/adherence of diabetes patients. From GPs point of view, this long for teamwork fits with emerging international evidence stating that structured [33] and patient oriented [34] care result in better outcomes. This new model of care fits quite well with our medical paradigms, but might be too much adaptedto the caregivers, without taking into account the views and priorities of (chronic) patients. It remains to be seen if structured care can also deliver a better long term care of patients with chronic illnesses. Don't we forget the patient in organizing shared care?
The cornerstones of health care to support active patient participation are to guarantee the continuity of care, to integrate education in health care and to encourage the patient's attendance [35]. An increased patient satisfaction may be contributing to improved clinical outcomes [36]. However, the relation between patients' satisfaction and GPs patient-centered behaviors remains unclear [37]. There is also limited and mixed evidence on the effects of patient centered interventions on patient health care behaviors or health status; or on whether these interventions might be applicable to providers other than physicians as diabetes-specialized nurses [38]. Professionals committed to achieving the benefits of patient centered consulting should take care not to lose the focus on disease while paying attention to the unique experience of illness of each patient [39]. Enhancing patient-provider agreement on both overall treatment goals and specific strategies to meet these goals may lead to improved patient outcomes [40].
Until now, little research has being done on the relationship between health care provider and compliance/adherence. For HIV patients, better treatment adherence is reported in those patients who perceived themselves to be more engaged with their health care provider [41]. However, since self-reported measures were used, this finding should be viewed with caution. Also in antidepressant treatments, the physician's attitude about the medication is a key factor for improving compliance [42].
A Canadian study on the role of patient, physician and system factors in the management of type 2 diabetes patients [43] shows very striking similarities with our study on compliance/adherence. Canadian GPs also believe that early educational interventions for patients with diabetes resulted in better outcomes. They also described the diabetes educational centers as a valuable resource and stressed the importance of referring the patient soon after diagnosis. In Canada, time and physician remuneration were identified as the main health system barriers to optimal diabetes management.
Qualitative research is often deemed to have lower reliability compared with experimental research. Yet, it has strong face validity, especially when it includes an observational component that enables the researcher to compare oral statements with actual practice [44]. In all our focus groups, all participating GPs spoke very spontaneous in an open atmosphere without any verbal aggression. However, in answering the questions, there was a clear sound of frustration in all five focus groups. Probably, that is a reason why some of the quotes sound rather punitive and blaming of patients. We never had the feeling that GPs were "set up" to respond in such a way. They react defensively because they feel powerless. They are afraid of decreasing income and standing by loosing patients in a fee-for-service payment with free entrance to all levels of care.
At least some limitations to our study have to be considered.
First, the topic of interest. Research in such a complicated matter as compliance/adherence is extremely difficult and always fragmentary, especially given the lack of a specific model or general theory. Different authors use "compliance", "concordance" and "adherence" haphazardly, complicating a comprehensive study of the literature [26]. Additional, for instance in Dutch, the three different meanings of compliance, concordance and adherence are interpreted only by one word. Though we presume in this context that "compliance" (doing what is told to be done) is the best translation, we prefer to use the combined term "compliance/adherence".
Second, the sampling. The participating GPs in this study were all volunteering and interested in a discussion on "problems diabetes patients might have to follow treatment recommendations", as mentioned in the introduction letter. Perhaps, volunteering GPs are more willing to discuss these difficult problems in the patient provider interaction. Since our sample fits well with age, gender and practice organization (table 2) of the Flemish GP population, we assume having described a maximal variation of answers. Besides, the main goal of our study was not to generate conclusions that could be generalized, but to explore and gain a deeper understanding of the GPs perspective of patient compliance/adherence. This limitation should also be taken into account by interpreting the results and before transferring the conclusions to other contexts. It could be argued that selecting GPs in different focus groups according to gender or experience could have been a more appropriate approach. The number of years in practice might be influence frustration. However, the provoked diversity of the group was meant to elicit a rich dynamic interaction in the conducted conversation.
Third, the analysis. While looking for barriers and solutions in patients' adherence GPs' frustration is an important issue in our results. GPs feel as if the patient does not consider them capable to treat their illness. However, a recent and extensive health inquiry in Belgium confirms the people's confidence in general medicine [45]. More, patients' own choice of a primary care physician seems to be associated with better adherence to their treatment regimes [46]. This relationship even remained significant after controlling for possible confounding factors as physician gender, patient gender or length of relationship. Perhaps GPs underestimate their potential value and the effect they can achieve with their patients. Rather than reflecting on themselves and making themselves familiar with newer communication skills, GPs shift the blame of failing on an inappropriate system or other extrinsic factors (e.g. cultural and social problems).
Patients, especially those with chronic illness, make decisions about treatments that fit with their own beliefs and personal circumstances. They may have clear reasons, narrowly related to their health beliefs, for adhering or not adhering to treatment recommendations.
The shared decision making process is rather complex. A joint patient-provider perspective is needed. Health care professionals should assess patients' reasons and beliefs in order to achieve agreement on attainable treatment goals. They need to shift the emphasis away from attempting to directing patients into take the medication they prescribe, towards learning how they can contribute to the decisions that patients currently make about their medications [47].
Adherence to treatment is therefore the shared responsibility of patients and GPs. In complex treatment plans, as is the case in diabetes, a possible way of helping people being adherent perhaps is helping them making more explicit their own attainable priorities. Exploring thepatient's expectations towards the disease and its treatment and translating these individual expectations to realizable and realistic objectives for the patient and in concert with the patient, is an important communication task for the GP. In fact, it is patients who should be the primary actors in medical decision-making, and the health professionals should adopt a supportive role. This joint patient-provider interaction could be a real contribution to a more positive approach on diabetes care. It will help patients to set their own desirable goals and give the GPs' consult again more value and depth. . In essence, then, compliance is an elusive, flexible goal.

Conclusion
The patient's own expectations with regard to illness and health not always correspond to the objectives and expectations of the physician's treatment proposals. The motivation of the physician to achieve a good result may be in conflict with the patient's own motivation to lead his own life. GPs seem to be in need of communication skills to integrate the various expectations of physicians and patients regarding diabetes care.
Our findings suggest a necessary shift to a model of patient-provider-partnership with mutual agreement on shared decisions. A closer relationship wherein the patient is more engaged to his treating GP possibly could reduce frustration.
Shared care, referred by these GPs as a possible solution for better compliance/adherence, only can fulfill these purpose if, from the beginning, the patients' perspectives and concerns are not forgotten.