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Table 3 New findings

From: Determinants of vitamin B12 deficiency in patients with type-2 diabetes mellitus — A primary-care retrospective cohort study

Clinical Impact

What is New

 • Risk factors that can help case-find B12 deficiencies (in primary-care patients with T2DM) are identified and compared

 • The odds of B12 deficiency increase markedly when “metformin daily dose” is ≥ 1.5 g/day”; and “age is ≥ 80 years”

 • Folate (B9) and B12 deficiencies are associated in our cohort; potentially amplifying the complications of deficiencies of these closely related B-vitamins

 • “Metformin daily dose” is an accurate proxy of both cumulative metformin exposure and duration of T2DM

Clinical Implications

 • We now have the framework to case-find and prevent B12 deficiencies in primary-care patients with T2DM