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Table 2 Association between potentially explanatory factors and the proportion of first opioid prescriptions prescribed together with a laxativea

From: Adherence to coprescribing of laxatives with opioids and associated characteristics in general practices in the Netherlands

 

OR (95% CI)

B(SE)

P-value

McKelvey & Zavoina Pseudo R2

Quality of registration

 Episodes with a meaningful diagnosis

   

0.047

     0–70% of episodes

ref

  

     More than 70% of episodes

1.59 (1.26–2.01)

0.46 (0.12)

 < 0.001

 Contacts linked to an episode

   

0.047

     0–80% of contacts

ref

  

     More than 80% of contacts

0.61 (0.47–0.80)

-0.49 (0.14)

 < 0.001

Collaboration

 Participation in pharmacotherapy audit meetings

   

0.043

 Yes

ref

  

 No

1.20 (0.68–2.10)

0.18 (0.29)

0.53

 Number of procedures with pharmacist

   

0.043

 0–5 topics

ref

  

 6–8 topics

1.05 (0.77–1.41)

0.046 (0.15)0.13 (0.16)

0.77

 9–10 topics

1.13 (0.83–1.55)

 

0.43

 Agreement with pharmacist on coprescribing laxative

   

0.045

 No

ref

  

 Yes

1.32 (0.92–1.89)

0.28 (0.18)

0.13

Use of an electronic clinical decision support system (%)

 Always

ref

  

0.044

 In half or more than half of all prescriptions

0.98 (0.70–1.38)

-0.019(0.17)-0.11 (0.16)-0.23

0.91

 In less than half of all prescriptions

0.89 (0.65–1.22)

(0.16)

0.49

 Never to hardly ever

0.80 (0.58–1.09)

 

0.16

Agree with guideline recommendations

  

 Yes

ref

  

0.044

 No

1.56 (0.93–2.62)

0.44 (0.26)

0.091

  1. In bold: significantly associated based on bonferroni corrected p-value of 0.0071
  2. aEach of the variables was tested in separate multilevel analyses, familiarity with the recommendation was not tested, as almost all GPs were familiar with the recommendation