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Table 5 Achievement of LDL treatment target (LDL < 2.5 mmol/l) by the changes in use of lipid lowering medication

From: Mode of treatments and achievement of treatment targets among type 2 diabetes patients with different comorbidities – a register-based retrospective cohort study in Finland

 

Changes in the use of lipid lowering medication

Overall achievement of treatment target

Intensification of medication

No change in medication

De-intensification of medication

Patient categories a

    

T2D only

(n = 500)

(n = 2264)

(n = 137)

(n = 2901)

Proportion of patients undergoing changes in lipid medication, %

17.2

78.0

4.7

 

Target met 2011-12, %

30.4

52.7

30.7

47.8

Target met 2015-16, %

62.0

57.4

19.7

56.4

Change in achievement of treatment target (%)

31.6

4.7

-11.0

8.6

T2D + CVD

(n = 295)

(n = 1458)

(n = 92)

(n = 1845)

Proportion of patients undergoing changes in lipid medication, %

16.0

79.0

5.0

 

Target met 2011-12, %

49.5

70.1

48.9

65.7

Target met 2015-16, %

71.9

73.7

39.1

71.7

Change in achievement of treatment target (%)

22.4

3.6

-9.8

6

T2D + AMD

(n = 86)

(n = 495)

(n = 27)

(n = 608)

Proportion of patients undergoing changes in lipid medication, %

14.1

81.4

4.4

 

Target met 2011-12, %

16.3

53.3

44.4

47.7

Target met 2015-16, %

57.0

58.2

14.8

56.1

Change in achievement of treatment target (%)

40.7

4.9

-29.6

8.4

T2D + CVD + AMD

(n = 46)

(n = 248)

(n = 16)

(n = 310)

Proportion of patients undergoing changes in lipid medication, %

14.8

80.0

5.2

 

Target met 2011-12, %

34.8

67.7

43.8

61.6

Target met 2015-16, %

67.4

70.6

18.8

67.4

Change in achievement of treatment target (%)

32.6

2.9

-25.0

5.8

P-value b

0.043

0.983

0.318

0.731

  1. (a) Patient selection criteria: Age ≥ 20, alive by the end of 2016 and whose LDL measured both in 2011-12 and 2015-16 (n = 5664). (b) P-value for the differences in the changes in use of lipid lowering medication during the follow-up between different patient groups; logistic regression models with GEE. Adjustment for age and sex did not change the P-value. CVD = cardiovascular disease (I20-I25, I46, I48, I50, I63-I66 (except I63.6) and G45), AMD = any mental disorder (ICD-10 code F00-F03, F20-F48 & G30)