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Table 2 Change in the prescription rate of medications by therapeutic class

From: Drugs utilization profile in England and Wales in the past 15 years: a secular trend analysis

Therapeutic class Rate of prescribing in 2004 per 100,000 persons (95% CI) Rate of prescribing in 2019 per 100,000 persons (95% CI) Percentage change from 2004 – 2019
Gastro-intestinal system medications 103,465.69 (103,439.86 – 103,491.52) 180,617.77 (180,586.84 – 180,648.69) 74.6%
Cardiovascular system medications 407,305.61 (407,263.94 – 407,347.28) 584,695.14 (584,655.52 – 584,734.76) 43.6%
Respiratory system medications 102,509.91 (102,484.19 – 102,535.64) 130,550.51 (130,523.43 – 130,577.60) 27.4%
Central nervous system medications 247,629.78 (247,593.18 – 247,666.39) 381,689.81 (381,650.75 – 381,728.86) 54.1%
Infections medications 82,616.61 (82,606.44 – 82,626.77) 74,498.74 (74,487.66 – 74,509.82) -9.8%
Endocrine system medications 109,310.42 (109,283.96 – 109,336.88) 200,804.09 (200,771.88 – 200,836.29) 83.7%
Obstetrics, gynaecology, and urinary-tract disorders medications 32,262.91 (32,250.38 – 32,275.45) 54,914.09 (54,901.44 – 54,926.74) 70.2%
Malignant disease and immunosuppression medications 8,029.08 (8,021.80 – 8,036.37) 8,385.11 (8,378.07 – 8,392.16) 4.4%
Nutrition and blood-related products 42,954.03 (42,936.83 – 42,971.22) 108,515.77 (108,490.76 – 108,540.77) 152.6%
Musculoskeletal and joint diseases medications 59,759.91 (59,746.76 – 59,773.06) 56,369.73 (56,357.12 – 56,382.34) -5.7%
Eye medications 31,691.22 (31,678.75 – 31,703.70) 33,348.64 (33,336.65 – 33,360.62) 5.2%
Ear, nose, and oropharynx medications 18,844.39 (18,833.90 – 18,854.88) 20,726.21 (20,715.90 – 20,736.51) 10.0%
Skin medications 69,938.78 (69,926.49 – 69,951.08) 57,095.46 (57,082.88 – 57,108.05) -18.4%
Immunological products and vaccines 27,124.69 (27,112.77 – 27,136.62) 22,835.83 (22,825.15 – 22,846.50) -15.8%
Anaesthesia 1,652.72 (1,649.30 – 1,656.14) 3,091.59 (3,087.19 – 3,095.99) 87.1%