Economic evaluation of a Decision Support Tool to guide intensity of mental health care in general practice: the Link-me pragmatic randomised controlled trial

Chatterton, Mary Lou; Harris, Meredith; Burgess, Philip; Fletcher, Susan; Spittal, Matthew J.; Faller, Jan; Palmer, Victoria J.; Chondros, Patty; Bassilios, Bridget; Pirkis, Jane; Gunn, Jane; Mihalopoulos, Cathrine

doi:10.1186/s12875-022-01839-z

Table 3 Quality adjusted life years (QALYs) calculated from EQ-5D-5L preference-based utility values, according to trial arm, in total sample and stratified by prognostic group

From: Economic evaluation of a Decision Support Tool to guide intensity of mental health care in general practice: the Link-me pragmatic randomised controlled trial

All participants	p value	Minimal/mild symptom group	p value	Severe symptom group		p value
Comparison, n	837		416		421
Intervention, n	834		414		420
Baseline to 6 months
Mean QALYs (SD) [1]
Comparison	0.610 (0.281)		0.776 (0.162)		0.445 (0.275)
Intervention	0.606 (0.285)		0.776 (0.163)		0.439 (0.282)
Mean difference, Coef. (95% CI)
Primary analysis [2]	-0.004 (-0.024 to 0.017)	.733	-0.004 (-0.025to 0.018)	.737	-0.002 (-0.036 to 0.033)	.922
Sensitivity analysis [3]	-0.002 (-0.027 to 0.023)	.883	0.000 (-0.026 to 0.025)	.991	-0.002 (-0.044 to 0.040)	.927
Sensitivity analysis [4]	-0.002 (-0.026 to 0.023)	.901	0.001 (-0.025 to 0.026)	.967	-0.002 (-0.044 to 0.040)	.931
Sensitivity analysis [5]	0.004 (-0.010 to 0.017)	.620	-0.001 (-0.016 to 0.013)	.840	0.009 (-0.013 to 0.031)	.407
Sensitivity analysis [6]	-0.002 (-0.018 to 0.013)	.782	0.000 (-0.015 to 0.012)	.900	-0.001 (-0.029 to 0.026)	.926
Baseline to 12 months
Mean QALYs (SD) [1]
Comparison	0.621 (0.287)		0.779 (0.173)		0.465 (0.287)
Intervention	0.613 (0.282)		0.772 (0.166)		0.456 (0.294)
Mean difference, Coef. (95% CI)
Primary analysis [2]	-0.008 (-0.029 to 0.014)	.481	-0.001 (-0.033 to 0.013)	.400	-0.004(-0.041 to 0.033)	.831
Sensitivity analysis [3]	-0.002 (-0.027 to 0.023)	.883	-0.000 (-0.026 to 0.025)	.991	-0.002 (-0.044 to 0.040)	.927
Sensitivity analysis [4]	-0.002 (-0.026 to 0.023)	.901	0.001 (-0.025 to 0.026)	.967	-0.002 (-0.044 to 0.040)	.931
Sensitivity analysis [5]	0.004 (-0.010 to 0.017)	.620	-0.001 (-0.016 to 0.013)	.840	0.009 (-0.013 to 0.031)	.407
Sensitivity analysis [6]	-0.006 (-0.022 to 0.011)	.506	-0.006 (-0.020 to 0.008)	.414	-0.003 (-0.033 to 0.026)	.827

SD Standard deviation, Coef. Estimated coefficient, CI Confidence interval
[1] Estimated using multiple imputation. [2] Mean for intervention arm minus mean for comparison arm estimated using generalized linear models (Gaussian family, identity link) adjusted for baseline K10 (all models) and prognostic group (model with all participants only). Estimated using multiple imputation. [3] Sensitivity analysis using complete cases only using generalized linear models (Gaussian family, identity link) adjusted for baseline K10 (all models) and prognostic group (model with all participants only). [4] Same as [3] but adjusted for general practice. [5] Sensitivity analysis using multiple imputation adjusted for baseline EQ-5D utility value. [6] Sensitivity analysis using utility values calculated with the UK value set for the EQ-5D-5L, estimated using multiple imputation and generalized linear models (Gaussian family, identity link) adjusted for baseline K10 (all models) and prognostic group (model with all participants only)

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