| All participants | p value | Minimal/mild | p value | Severe | p value |
---|---|---|---|---|---|---|
prognostic group | prognostic group | |||||
Comparison, n | 837 | Â | 416 | Â | 421 | Â |
Intervention, n | 834 | Â | 414 | Â | 420 | Â |
6Â months | ||||||
 Mean cost (SD) [1] | ||||||
  Comparison | $1,247 (4,473) |  | $304 (1,045) |  | $2,178 (6,057) |  |
  Intervention | $2,231 (6,716) |  | $429 (1,150) |  | $4,006 (8,984) |  |
Mean difference, Coef. (95% CI) | ||||||
 Primary analysis [2] | $24 (9 to 44) | p < 0.0001 | $28 (-5 to 79) | 0.106 | $340 (126 to 644) | p < 0.0001 |
 Sensitivity analysis [3] | $20 (6 to 40) | 0.002 | $20 (-4 to 60) | 0.108 | $227 (45 to 514) | 0.009 |
 Sensitivity analysis [4] | $24 (7 to 46) | 0.002 | $17 (-2 to 50) | 0.092 | $320 (94 to 669) | 0.002 |
 Sensitivity analysis [5] | $23 (9 to 42) | p < 0.0001 | $29 (-3 to 78) | 0.078 | $287 (96 to 554) | 0.001 |
12Â months | ||||||
 Mean cost (SD) [1] | ||||||
  Comparison | $2,787 (9,879) |  | $640 (1,801) |  | $4,908 (13,498) |  |
  Intervention | $3,871 (12,178) |  | $991 (2,448) |  | $6,710 (16,476) |  |
Mean difference, Coef. (95% CI) | ||||||
 Primary analysis [2] | $50 (10 to 102) | 0.011 | $59 (6 to 134) | 0.025 | $645 (-152 to 1,818) | 0.128 |
 Sensitivity analysis [3] | $31 (9 to 64) | 0.003 | $31 (-15 to 114) | 0.108 | $366 (86 to 802) | 0.005 |
 Sensitivity analysis [4] | $31 (8 to 62) | 0.003 | $23 (-10 to 82) | 0.214 | $492 (143 to 1,031) | 0.002 |
 Sensitivity analysis [5] | $48 (8 to 99) | 0.014 | $59 (9 to 131) | 0.018 | $538 (-219 to 1,651) | 0.19 |
 Sensitivity analysis [6] | $1 (-26 to 47) | 0.974 | -$3 (-39 to 59) | 0.911 | $242 (-1,261 to 3,673) | 0.822 |