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Table 2 FIT sensitivities/specificities at various Hb cut offs and modelling data for CRC

From: Cost effectiveness of using Faecal Immunochemical Testing (FIT) as an initial diagnostic investigation for patients with lower gastrointestinal symptoms suggestive of malignancy

Hb Threshold Sensitivity 95% CI Specificity 95% CI True +  True - False +  False - PPV (%) NPV (%)
4 μg 97.2 85.5–99.9 88.4 58.1–92.7 26 1895 258 0.8 2 99.9
10 μg 92.1 86.9–95.3 85.8 78.3–90.1 26 1895 314 2 7.5 99.8
15 μg 92.3 86.6–96.1 86.9 85.6–88.1 26 1895 286 2 8.2 99.8
20 μg 89.5 84.9–93.1 86.6 85.4–87.7 26 1895 293 3 8 99.8