Age groups: | All | < 50 years | 50–75 years | ≥ 75 years | p value |
---|---|---|---|---|---|
Total number, n (%) | 172 (100) | 48 (27.9) | 82 (47.7) | 42 (24.4) | |
Sociodemographic variables | |||||
Age, mean (SD), years | 60.5 (17.0) | 39.0 (8.3) | 62.1 (6.5) | 81.9 (5.5) | < 0.001 |
Sex, n (%) | |||||
Female | 87 (50.6) | 25 (52.0) | 32 (39) | 30 (71) | 0.003 |
Male | 85 (49.4) | 23 (48.0) | 50 (61) | 12 (29) | |
Comorbidities | |||||
Cardiovascular risk factor | |||||
Smoke habit, n (%) | 13 (7.6) | 3 (6) | 10 (12) | 0 (0) | 0.062 |
BMI ≥ 25 kg/m2, n (%) | 90 (52.3) | 16 (33) | 51 (62) | 23 (55) | 0.012 |
Hypertension, n (%) | 83 (48.3) | 6 (12) | 39 (48) | 38 (90) | < 0.001 |
type 2 Diabetes, n (%) | 33 (19.2) | 0 (0) | 21 (26) | 12 (29) | < 0.001 |
Dyslipidemia, n (%) | 68 (39.5) | 11 (23) | 32 (39) | 25 (60) | 0.002 |
Respiratory diseases | |||||
Asthma, n (%) | 21 (12.2) | 4 (8) | 7 (9) | 10 (24) | 0.031 |
COPD, n (%) | 9 (5.2) | 1 (2) | 5 (6) | 3 (7) | 0.50 |
Cardiovascular diseases | |||||
Ischaemic heart diseases, n (%) | 9 (5.2) | 0 (0) | 3 (4) | 6 (14) | 0.007 |
Arrhythmias, n (%) | 10 (5.8) | 1 (2) | 2 (2) | 7 (17) | 0.003 |
Heart failure, n (%) | 7 (4.1) | 0 (0) | 3 (4) | 4 (10) | 0.072 |
Other diseases | |||||
Chronic kidney diseases, n (%) | 12 (7.0) | 0 (0) | 3 (4) | 9 (21) | < 0.001 |
Cognitive impairment, n (%) | 10 (5.8) | 1 (2) | 1 (1) | 8 (19) | < 0.001 |
Cancer, n (%) | 10 (5.8) | 0 (0) | 4 (5) | 6 (14) | 0.014 |
Rheumatological diseases, n (%) | 14 (8.1) | 3 (6) | 6 (7) | 5 (12) | 0.58 |
Chronic treatment | |||||
no drugs, n (%) | 33 (19.2) | 19 (40) | 14 (17) | 0 (0) | < 0.001 |
1–4 drugs, n (%) | 68 (39.5) | 25 (52) | 35 (43) | 8 (19) | |
5–9 drugs, n (%) | 43 (25.0) | 3 (6) | 20 (24) | 20 (48) | |
≥ 10 drugs, n (%) | 28 (16.3) | 1 (2) | 13 (16) | 14 (33) | |
Antithrombotic/anticoagulant treat | |||||
Antithrombotic drug, n (%) | 14 (8.1) | 1 (2) | 7 (9) | 6 (14) | 0.019 |
Anticoagulant drug, n (%) | 8 (4.7) | 1 (2) | 2 (2) | 5 (12) | |
Non consumption, n (%) | 150 (87.2) | 46 (96) | 73 (89) | 31 (74) | |
Symptoms | |||||
Fever, n (%) | 144 (83.7) | 41 (85) | 74 (90) | 29 (69) | 0.003 |
Cough, n (%) | 140 (81.4) | 43 (90) | 68 (83) | 29 (69) | 0.039 |
Dyspnea, n (%) | 103 (59.9) | 29 (60) | 50 (61) | 24 (57) | 0.91 |
Gastrointestinal disturbances, n(%) | 72 (41.9) | 23 (48) | 32 (39) | 17 (40) | 0.60 |
Myalgias, n (%) | 51 (29.7) | 15 (31) | 30 (37) | 6 (14) | 0.035 |
Thoracic Pain, n (%) | 27 (15.7) | 17 (35) | 9 (11) | 1 (2) | < 0.001 |
Pleural chest Pain, n (%) | 10 (5.8) | 4 (8) | 6 (7) | 0 (0) | 0.17 |
Rhinitis, n (%) | 8 (4.7) | 4 (8) | 4 (5) | 0 (0) | 0.17 |
Odynophagia, n (%) | 20 (11.6) | 8 (17) | 8 (10) | 4 (10) | 0.44 |
Asthenia, n (%) | 47 (27.3) | 13 (27) | 20 (24) | 14 (33) | 0.57 |
Headache, n (%) | 47 (27.3) | 13 (27) | 20 (24) | 14 (33) | 0.57 |
Dysgeusia, n (%) | 9 (5.2) | 6 (12) | 3 (4) | 0 (0) | 0.020 |
Anosmia, n (%) | 2 (1.2) | 1 (2) | 1 (1) | 0 (0) | 0.65 |
Symptoms categorized | |||||
1–3 total symptoms, n (%) | 97 (56.7) | 20 (42) | 41 (51) | 36 (86) | < 0.001 |
≥ 4 total symptoms, n (%) | 74 (43.3) | 28 (58) | 40 (49) | 6 (14) | |
Physical examination | |||||
Temperature, median (IQR), ºC | 37.2 (36.7, 37.8) | 37.3 (0.8) | 37.4 (0.8) | 37.0 (0.8) | 0.060 |
Heart rate, mean (SD), bpm | 93.2 (16.1) | 99.6 (13.8) | 93.3 (16.5) | 85.9 (15.1) | < 0.001 |
Respiratory rate, (median (IQR), rpm | 16.0 (15.0, 21.0) | 16.0 (15.0, 16.0) | 18.0 (15.5, 21.0) | 22.0 (15.0, 25.0) | 0.028 |
Pulse oximetry, median (IQR), % | 94.0 (92.0, 96.5) | 96.0 (94.0, 97.5) | 94.0 (92.0, 96.0) | 92.0 (88.5, 94.0) | < 0.001 |
Normal lung auscultation, n (%) | 38 (22.1) | 13 (27) | 21 (26) | 4 (10) | 0.16 |
Abnormal lung auscultation, n (%) | 54 (31.4) | 12 (25) | 24 (29) | 18 (43) | 0.16 |
Blood test | |||||
CRP, median (IQR), mg/L | 65.3 (29.0, 128.0) | 57.0 (12.8, 115.0) | 60.9 (34.0, 135.0) | 81.5 (45.0, 133.0) | 0.32 |
Lymphocytes, median (IQR), 10e3/ml | 1100.0 (800.0, 1500.0) | 1250.0 (1000.0, 1750.0) | 1000.0 (800.0, 1400.0) | 900.0 (600.0, 1200.0) | 0.002 |
D-Dimer, median (IQR), μg/L | 445.0 (288.0, 910.0) | 410.0 (240.0, 901.5) | 460.0 (270.0, 880.0) | 464.0 (320.0, 2160.0) | 0.39 |
Fibrinogen ≥ 500, n (%), mg/dL | 127 (73.8) | 31 (65) | 62 (76) | 34 (81) | 0.29 |
Ferritin, median (IQR), μg/L | 443.5 (200.0, 1215.0) | 474.0 (320.0, 1738.0) | 494.0 (203.0, 913.0) | 325.5 (184.5, 1006.5) | 0.73 |
RT-PCR SARS-CoV-2 | |||||
Negative, n (%) | 36 (20.9) | 17 (35) | 13 (16) | 6 (14) | 0.041 |
Positive, n (%) | 122 (70.9) | 27 (56) | 64 (78) | 31 (74) | 0.042 |
Pneumonia features | |||||
Pneumonia onset, mean (SD), days | 7.8 (4.1) | 8.1 (4.7) | 8.3 (3.8) | 6.7 (3.7) | 0.12 |
Unilateral, n (%) | 46 (26.7) | 21 (44) | 19 (23) | 6 (14) | 0.003 |
Bilateral, n (%) | 126 (73.3) | 27 (56) | 63 (77) | 36 (86) | 0.004 |
Complications | |||||
Hospital admission, n (%) | 140 (81.4) | 30 (62) | 68 (83) | 42 (100) | < 0.001 |
Pulmonary thromboembolism, n (%) | 7 (4.1) | 2 (4) | 2 (2) | 3 (7) | 0.45 |
Death, n (%) | 11 (6.4) | 0 (0) | 2 (2) | 9 (21) | < 0.001 |