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Table 1 Clinical manifestations of ATTRv and ATTRwt amyloidosis

From: Avoiding misdiagnosis: expert consensus recommendations for the suspicion and diagnosis of transthyretin amyloidosis for the general practitioner

  ATTRv ATTRwt References
Age at symptom onset > 20 years > 50 years [8,9,10,11,12]
Male, % 76–86 91–97 [13,14,15]
Duration of symptoms before diagnosis ~ 3 years ~ 2 years [8, 9, 11]
Median life expectancy, after diagnosis • 2–5 years with predominantly CM
• 8–10 years with predominantly PN
4 years [9, 12, 16, 17]
Clinical manifestation
Cardiac Yes Yes [13, 18, 19]
Peripheral nerves Yes Occasionally [13, 18]
Autonomic nerves (including gastrointestinal) Yes Rare [13, 18, 20, 21]
Kidney Yes Rare [1, 13]
Ophthalmologic Vitreous deposition Not prominent [1]
Musculoskeletal Yes Yes [13, 22,23,24,25,26,27,28]
  1. ATTRv Hereditary ATTR amyloidosis, ATTRwt Wild-type ATTR amyloidosis, CM Cardiomyopathy, PN Polyneuropathy