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Table 3 Numbers, proportions and odds ratios (95% CI) for features in cases of ankylosing spondylitis compared with symptomatic controls

From: Clinical features in primary care electronic records before diagnosis of ankylosing spondylitis: a nested case-control study

 

Occurrence of features in 3 years before index date

Occurrence of features at any time before index date

 

Cases (N = 74)

Controls (N = 169)

 

Cases (N = 74)

Controls (N = 169)

 

Specific features

N

%

N

%

OR

(95% CI)

N

%

N

%

OR

(95% CI)

Axial pain

39

52.7

93

55.0

1.0

(0.6, 1.8)

49

66.2

146

86.4

0.3

(0.2, 0.6)

Other spine diagnosis

16

21.6

25

14.8

1.8

(0.8, 3.9)

22

29.7

40

23.7

1.4

(0.7, 2.7)

Sciatica

5

6.8

19

11.2

0.6

(0.2, 1.7)

9

12.2

31

18.3

0.7

(0.3, 1.4)

Large joint symptom

14

18.9

14

8.3

2.1

(0.9, 4.8)

22

29.7

34

20.1

1.5

(0.8, 2.9)

Other joint symptom

5

6.8

4

2.4

2.7

(0.6, 12.5)

7

9.5

6

3.6

2.8

(0.8, 10.3)

Tendon disorders

9

12.2

10

5.9

2.1

(0.8, 5.5)

16

21.6

21

12.4

1.7

(0.8, 3.6)

Iritis

8

10.8

0

0.0

12

16.2

0

0.0

Urethral symptoms

2

2.7

1

0.6

3

4.1

4

2.4

1.5

(0.3, 6.8)

Fatigue

10

13.5

14

8.3

2.1

(0.8, 5.7)

12

16.2

22

13.0

1.3

(0.5, 3.1)

Inflamm. Bowel disease

7

9.5

2

1.2

12.0

(1.5, 99.4)

12

16.2

9

5.3

3.2

(1.3, 7.8)

Other Inflamm. arthritis

3

4.1

2

1.2

5

6.8

4

2.4

2.5

(0.7, 9.5)

X-ray spine

6

8.1

2

1.2

12.6

(1.5, 106.7)

7

9.5

3

1.8

13.7

(1.6, 113.6)

X-ray pelvis

2

2.7

0

0.0

2

2.7

1

0.6

16.2

18

10.7

3.2

(1.0, 10.8)

15

20.3

23

13.6

4.6

(1.2, 17.5)

ESR

6

8.1

1

0.6

14.3

(1.7, 120.8)

7

9.5

2

1.2

14.5

(1.8, 120.7)

MRI scan

NA

NA

NA

NA

0

0.0

2

1.2

NSAIDs

52

70.3

70

41.4

3.6

(1.8, 7.1)

57

77.0

94

55.6

3.1

(1.4, 6.6)

Analgesics

37

50.0

53

31.4

2.0

(1.1, 3.6)

41

55.4

77

45.6

1.4

(0.8, 2.5)

Opioids

8

10.8

10

5.9

1.8

(0.7, 4.7)

10

13.5

13

7.7

1.8

(0.8, 4.2)

Tricyclic antidepressants

10

13.5

14

8.3

1.6

(0.7, 3.8)

12

16.2

20

11.8

1.3

(0.6, 3.0)

SSRI antidepressants

5

6.76

24

14.2

0.37

(0.1, 1.1)

9

12.16

33

19.5

0.51

(0.2, 1.2)

  1. Features: Large Joint symptom codes relating to large limb joints (shoulder-wrist, hip-ankle); Other joint symptoms codes relating to joints distal to wrist/ ankle; ESR Erythrocyte sedimentation rate, MRI Magentic resonance imaging, NSAID Non-steroidal anti-inflammatory drugs, Analgesics paracetamol, codeine, Opioids opioid drugs of the potency of tramadol or higher, SSRI Selective Serotonin Reuptake Inhibitor & related antidepressants; Index date: date of diagnosis for cases, date of diagnosis of matched case for controls