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Table 5 Characteristics of antihypertensive pharmacotherapy in urban, rural and island environment of South Croatia

From: Effectiveness of treatment of newly diagnosed hypertension in family medicine practices in South Croatia

Pharmacotherapy Urban area (n = 56)a Rural area (n = 75)a Island area (n = 66)a P b
First-line treatment (n, (%))
 1. Diuretics 3 (5.4) 8 (10.7) 1 (1.5) 0.037
 2. ACE inhibitors (ACEI) 14 (25.0) 21 (28.0) 15 (22.7)
 3. Calcium channel blockers (CCB) 16 (28.6) 5 (6.7) 9 (13.6)
 4. Angiotensin II receptor blockers (ARB) 0 (0.0) 0 (0.0) 1 (1.5)
 5. β-adrenergic receptor blockers (BB) 5 (8.9) 8 (10.7) 14 (21.2)
 7. Fixed-dose combination:c 8 (14.3) 12 (16.0) 7 (10.6)
 ACEI + diuretic 5 (8.9) 9 (12.0) 5 (7.6)
 BB + diuretic 2 (3.6) 0 (0.0) 2 (3.0)
 ARB + diuretic 0 (0) 1 (1.3) 0 (0.0)
 ACEI + CCB 1 (1.8) 2 (2.7) 0 (0.0)
 8. > 1 medications (2 or 3)c 10 (17.9) 21 (28.0) 19 (28.8)
One-year treatment (median, 95% CI)
 Total daily number of pills per patientd 1.5 (1.0–2.0) 1.5 (1.0–2.0) 2 (1.0–2.6) 0.217
 Total annual number of drugs per patient 1 (1.0–2.0) 2 (1.0–2.0) 1 (1.0–2.0) 0.135e
  1. aExcluded participants without pharmacological treatment during the first treament year (n = 16)
  2. bχ2 test
  3. cFixed-dose combination of two active pharmaceutical ingredients is considered as one drug
  4. dCalculated average total daily number of pills per each patient (since the number of pills varied during a following year) was used to calculate the median of total daily number of pills for urban, rural and island enironment
  5. eKruskal-Wallis test