From: How general practitioners would deprescribe in frail oldest-old with polypharmacy — the LESS study
History of CVD | p-value1 | ||||
---|---|---|---|---|---|
No | Yes | ||||
Medication | Percentage of GPs (95% CI) | Reasons to deprescribe (frequency) | Percentage of GPs (95% CI) | Reasons to deprescribe (frequency) | |
Atorvastatin 40 mg | 100% | - Not enough benefit (56) - No indication (35) - No evidence (16) - Short estimated life expectancy (16) | 76% (69–83%) | - Not enough benefit (30) - Other (25) - Short estimated life expectancy (19) | < 0.001 |
Pantoprazole 20 mg | 88% (83–93%) | - No indication (111) - In reserve, no long-term therapy (6) - Not enough benefit (5) | 81% (75–87%) | - No indication (90) - Not enough benefit (7) | 0.002 |
Aspirin 100 mg | 74% (67–81%) | - No indication (55) - Not enough benefit (19) - Side effects (15) | 32% (25–40%) | - Other (13) - Side effects (9) - Short life expectancy (8) | < 0.001 |
Tramadol 50 mg | 71% (63–78%) | - Side effects (76) - Lower drug dose (8) - In reserve, no long-term therapy (8) | 70% (63–77%) | - Side effects (69) - Lower drug dose (9) - In reserve, no long-term therapy (8) | 0.71 |
Amlodipine 5 mg | 44% (36–52%) | - No indication (22) - Side effects (22) - Not enough benefit (7) - Deprescribe the drug and evaluate the effect (7) | 36% (28–44%) | - No indication (21) - Side effects (9) - Other (7) | 0.011 |
Paracetamol 1 g | 29% (22–37%) | - Lower drug dose (13) - In reserve, no long-term therapy (13) - Deprescribe the drug and evaluate the effect (6) | 29% (22–36%) | - Lower drug dose (14) - In reserve, no long-term therapy (10) - Deprescribe the drug and evaluate the effect (6) | 0.56 |
Enalapril 10 mg | 24% (17–31%) | - No indication (15) - Side effects (5) - Lower drug dose (4) | 19% (13–25%) | - No indication (13) - Lower drug dose (3) - Other (3) | 0.033 |