From: Prevalence of potential underlying aetiology of macrocytic anaemia in Dutch general practice
Cause | Definition |
---|---|
1) Vitamin B12 deficiency | Vitamin B12 < 130 pmol/L |
2) Folic acid deficiency | Folic acid < 5 nmol/L |
3) Possible bone marrow disease | Abnormal number leukocytes and thrombocytes Reticulocytes < 2.5 % |
4) Haemolysis | Raised LDH, reticulocytes > 2.5 %, bilirubin > 17 μmol/L |
5) Documented alcohol abuse | Documented in patient file by treating physician |
6) Anaemia of chronic disease (ACD) | Ferritin > 100 μg/L, serum transferrin < 2.0 g/L and/or serum iron < 14 μmol/L (men), < 10 μmol/L (women) |
7) Iron deficiency anaemia (IDA) | Ferritin < 25 μg/L (men), < 20 μg/L (women) |
8) Renal anaemia | Estimated creatinine clearance (MDRD) ≤ 45 mL/min/1.73 m2 (8) |
9) Other | Documented in patient file by treating physician |
10) Unknown | No cause could be determined |