Table 1 Symptoms and signs most frequently noted in those with CFS/ME

Aching muscles, 90 %+,

Pharyngitis, 25 %

Non-Restorative sleep, 95 %+

Cervical tenderness with or without lymphadenopathy 25 %

Daytime nap 3+ times per week, 30 %

Muscle weakness, 90 %+

Axillary lymph nodes 10 %

Impaired concentration, 90 %

Cold peripheries in moderate, severe and very severe ME −70 + %

Forgetfulness, 85 %

Muddled thinking, 80 %+

Aching joints, 85 %+

Temperature >37.5C but <39.0C, 10 %

Stress aggravated Fatigue, 90 %

Increased respiratory rate, 80 + %

Headaches 75 %

Altered pupil reflexes, 60 %

Weight gain, 50 %

Orthostatic intolerance 60 % [according to the IOM – [7]