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Table 5 Patient demographics and independent variables, including benzodiazepines and z-hypnotics

From: Patient factors associated with SSRI dose for depression treatment in general practice: a primary care cross sectional study

 

n = 1610

Unadjusted odds ratio (95% CI)

p-value

Mean Age ± SD (range) years

46 ± 12 (18 to 70)

1.00 (1.00 to 1.01)

0.432

Male (%)

551 (34.2)

1

 

Female (%)

1059 (65.8)

1.17 (0.93 to 1.46)

0.186

Deprivation (%)

  SIMD quintile 1 (least deprived)

93 (5.9)

1

 

  SIMD quintile 2

153 (9.7)

0.92 (0.50 to 1.70)

0.794

  SIMD quintile 3

90 (5.7)

1.75 (0.90 to 3.43)

0.101

  SIMD quintile 4

264 (16.7)

1.29 (0.73 to 2.28)

0.373

  SIMD quintile 5 (most deprived)

985 (62.1)

1.41 (0.82 to 2.44)

0.213

  SIMD unknown (not in mode)

25 (1.6)

  

Co-morbidities (%)

  0

1028 (63.9)

1

 

  1

415 (25.8)

1.20 (0.93 to 1.55)

0.152

  ≥2

167 (10.4)

1.12 (0.79 to 1.58)

0.533

Current Smoking Status (%)

  Non-smoker

900 (56.6)

1

 

  Smoker

691 (43.4)

1.16 (0.93 to 1.45)

0.192

  Smoking status unknown (not in model)

19 (1.2)

  

SSRI use (%)

  ADM for <2 y (%)

1143 (71.0)

1

 

  Same ADM for ≥2 y

467 (29.0)

1.94 (1.53 to 2.47)

<0.001

Practice (% practice pop.)

  1

82 (5.1)

1

 

  3

242 (15.0)

1.48 (0.77 to 2.83)

0.241

  6

201 (12.5)

2.78 (1.49 to 5.18)

0.001

  8

322 (20.0)

1.96 (1.07 to 3.58)

0.029

  9

181 (11.2)

4.17 (2.22 to 7.81)

<0.001

  10

302 (18.8)

2.60 (1.42 to 4.78)

0.002

  11

280 (17.4)

3.62 (1.98 to 6.66)

<0.001

B&Z use (%)

  None

1420 (88.2)

1

 

  Long-term B&Z for ≥8 weeks

190 (11.8)

2.05 (1.47 to 2.86)

<0.001

  1. CI: 95% confidence interval. SD: standard deviation. SIMD: Scottish Index of Multiple Deprivation. SSRI: selective serotonin re-uptake inhibitor. ADM: antidepressant medicine.
  2. Co-morbidities: Individuals had one or more of the following: asthma, COPD, cardiovascular disease, stroke, diabetes mellitus and/or hypertension.
  3. B&Z: bzodiazepine and/or z –hypnotic.