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Table 4 Results

From: Buprenorphine versus dihydrocodeine for opiate detoxification in primary care: a randomised controlled trial

  Buprenorphine (total 28) Dihydrocodeine (total 32) Odds Ratio (95% CI) Relative Risk (95% CI) P value
By end of detox
   Final urine sample 9 (32%) 4 (13%) 3.32 (0.77–15.22) 1.71 (1.04–2.83) 0.065
   Non-ITT Clean urine 6/9 (67%) 1/4 (25%) 6.00 (0.28–246) 1.71 (0.73–4.03) 0.164
   ITT-1* clean urine 6/28 (21%) 1/32 (3%) 8.45 (0.89–200) 2.06 (1.33–3.21) 0.028
   ITT-2* clean urine 6+3/28 1+8/32 1.21 (0.35–4.21) 1.11 (0.63–1.95) 0.735
   Leaving early 19 (68%) 28 (88%) 0.30 (0.07–1.30) 0.58 (0.35–0.96) 0.065
   Overdose 0 0 Not applicable
   Inappropriate use of allocated drug 0 0 Not applicable
   A&E attendance 0 0 Not applicable
   Admitted 0 0 Not applicable
   Overdose 0 0 Not applicable
   GP visits – mean 2.2 (1.05) 2.8 (1.33)    0.06
   Drug worker visits – mean 0.17 (0.47) 1.31 (0.59)    0.343
At 3 months post detoxification
   Abstinent 10/27 (37%) 4/24 (17%) 2.94 (0.67–13.78) 1.55 (0.96–2.52) 0.104
   Dead 0/27 0/28 Not applicable
   On Med 3 sick note 10/16 (63%) 6/14 (43%) 2.22 (0.41–12.65) 1.46 (0.71–2.98) 0.282
   A&E attendance 2/27 (7%) 2/28 (7%) 1.04 (0.09–11.46) 1.06 (0.38–2.94) 0.970
   Hospital attendance 1/27 (4%) 2/28 (7%) 0.5 (0.02–7.75) 0.67 (0.13–3.38) 0.574
   GP visits – mean 5.04 (4.85) 4.61 (4.10)    0.724
   Drug worker visits – mean 1.22 (1.67) 1.14 (1.53)    0.855
At 6 months post detoxification
   Abstinent 7/22 (32%) 3/19 (16%) 2.49 (0.45–15.15) 1.45 (0.84–2.49) 0.233
   Dead 0/23 0/20 Not applicable
   On Med 3 sick note 3/11 (27%) 2/11 (18%) 1.69 (0.16–20.05) 1.27 (0.53–3.06) 0.611
   A&E attendance 0/22 0/20 Not applicable
   Hospital attendance 0/22 2/20 (10%) 0.16 (0.01–3.64)   0.129
   GP visits – mean 7.54 (6.71) 6.48 (6.07)    0.582
   Drug worker visits – mean 1.74 (2.40) 2.65 (2.89)    0.265
  1. • Assumption 1 = everybody not returning for final urine test had not clean urine
  2. • Assumption 2 = everybody not returning for final urine test had same proportion of not clean urine as those who did