Table 4 Summary of Results from RCTs Comparing Ciclesonide to Budesonide or Fluticasone
Trial | Results CIC vs. comparator | ||||
|---|---|---|---|---|---|
Lung Function | |||||
Lee, Fardon et al | Authors report no significant difference (CIC vs. FP) | ||||
Lee, Haggart et al | Â | 95% CI for CIC vs. FP | Â | Â | Â |
| Â | FEV1 (l) | -0.15, 0.06 | Â | Â | Â |
Kanniess et al | Authors report no significant difference (CIC vs. BUD) | Â | Â | Â | Â |
Patient Symptoms | |||||
Lee, Fardon et al | Authors report no significant difference (CIC vs. FP) | ||||
Lee, Haggart et al | Â | Â | Â | Â | Â |
| Â | Â | 95% CI for CIC vs. FP | Â | Â | Â |
| Â | PEF (am) (l/min) | -12, 14 | Â | Â | Â |
| Â | PEF (pm) (l/min) | -11. 17 | Â | Â | Â |
| Â | Asthma symptom score (am) | -0.3, 0.1 | Â | Â | Â |
| Â | Asthma symptom score (pm) | -0.3, 0.1 | Â | Â | Â |
| Â | Rescue (am) (puffs/day) | -0.4, 0.2 | Â | Â | Â |
| Â | Rescue (am) (puffs/day) | -0.3, 0.1 | Â | Â | Â |
Quality of Life | |||||
Lee, Fardon et al | Authors report no significant difference (CIC vs. FP) | ||||
Lee, Haggart et al | Â | Â | Â | Â | Â |
| Â | Â | 95% CI for CIC vs. FP | Â | Â | Â |
| Â | Activities | -0.26, 0.92 | Â | Â | Â |
| Â | Symptoms | -0.45, 0.56 | Â | Â | Â |
| Â | Emotions | -0.76, 0.37 | Â | Â | Â |
| Â | Environment | -1.08, 0.02 | Â | Â | Â |
| Â | Overall | -0.43, 0.37 | Â | Â | Â |
Airway Responsiveness to Provoking Agent | |||||
Lee, Fardon et al | Â | Â | Â | Â | Â |
| Â | Â | CIC vs. FP | Â | ||
| Â | Â | GMFD | 95% CI | P | Â |
| Â | PC20 FEV1 (metacholine) | 0.1 | -0.7-0.5 | >0.05 | Â |
Lee, Haggart et al | Â | Â | Â | Â | Â |
| Â | Â | 95% CI for CIC vs. FP | Â | Â | Â |
| Â | PC20 FEV1 (metacholine) | -1.2, 0.4 | Â | Â | Â |
Kanniess et al | Authors report no significant difference (CIC vs. BUD) | ||||
Inflammatory Markers | |||||
Lee, Fardon et al | Â | Â | Â | Â | Â |
| Â | Â | CIC vs. FP | Â | ||
| Â | Â | GMFD | 95% CI | P | Â |
|  | Exhaled Nitric oxide | 1.4 | 0.8–2.5 | >0.05 |  |
Lee, Haggart et al | Â | Â | Â | Â | Â |
| Â | Â | 95% CI for CIC vs. FP | Â | Â | |
| Â | Exhaled Nitric oxide | -2.1, 7.3 | Â | Â | |
Kanniess et al | Authors report no significant difference (CIC vs. BUD) | ||||
HPA Suppression | |||||
Lee, Fardon et al | Â | Â | Â | Â | Â |
| Â | Â | CIC vs. FP | Â | ||
| Â | Â | GMFD | 95% CI | P | Â |
|  | Cortisol pre-hCRF | 1.1 | 0.9–1.2 | >0.05 |  |
|  | Cortisol 30 mins post-hCRF | 1.0 | 0.9–1.2 | >0.05 |  |
|  | OUC | 1.5 | 1.1–2.0 | <0.05 |  |
Oropharyngeal Deposition | |||||
Nave et al | Test | Reference | Point Estimates of Molar Adjusted AUC0–60 min Ratios | 95% CI | P value |
|  | des-CIC | BUD | 0.04 | 0.02 – 0.05 | < 0.0001 |
|  | des-CIC | CI C | 0.08 | 0.06 – 0.11 | < 0.0001 |
|  | des-CIC + CIC | BUD | 0.47 | 0.38 – 0.59 | < 0.0001 |
Richter et al | Â | Â | Â | Â | Â |
|  | Test | Reference | Point Estimates of Molar Adjusted AUC0–60 min Ratios | 95% CI | P value |
|  | des-CIC | FP | 0.08 | 0.05 – 0.11 | <0.00001 |
|  | des-CIC | CIC | 0.17 | 0.13 – 0.22 | <0.00001 |
|  | des-CIC + CIC | FP | 0.53 | 0.40 – 0.69 | <0.001 |