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Table 1 Summary of included studies in meta-analysis of remission rates.

From: Is remission of depressive symptoms in primary care a realistic goal? A meta-analysis

Study

Diagnostic Criteria

Follow up Period

Remission Criteria

Total N

Intervention

Intervention Remission Rate

Remission %

Psychological Intervention Only

Dowrick et al., 2000 [31]

DSM-IV criteria for MDD or Adjustment Disorder

6 months

No MDD detected by SCAN interview

425

• PST

• Usual Care

•Prevention course

• 58/128

• 76/189

• 44/108

• 45

• 38

• 41

Antidepressant Intervention Only

Benkert et al., 2000 [32]

DSM-IV criteria for MDD and HDRS ≥ 18

6 weeks

HDRS ≤ 7

275

• Mirtazapine

• Paroxetine

• 52/139

• 42/136

• 37

• 31

Patris et al.,1996 [33]

DSM-IIIR criteria for MDD

8 weeks

MADRS ≤ 12

357

• Citalopram

• Fluoxetine

• 114/173

• 110/184

• 66

• 60

Wade et al., 2002 [34]

DSM-IV criteria for MDD

8 weeks

MADRS ≤ 12

380

• Escitalopram

• Placebo

• 92/191

• 64/189

• 48

• 34

Psychological Intervention + Antidepressants

Chilvers et al., 2001 [35]

Diagnosed as MDD by GP

12 months

RDC <4, BDI <10, or clear documentation in GP notes that patient is well

103

Randomised only:

• Antidepressant

• Counselling

• 39/51

• 33/52

• 76

• 63

Mynors-Wallis et al., 1995 [36]

Diagnosed as MDD by GP

12 weeks

HDRS ≤ 7 or BDI ≤ 8

91

• PST

• Amitriptyline

• Placebo

• 18/30

• 16/31

• 8/30

• 60

• 52

• 27

Mynors-Wallis et al., 2000 [37]

RDC criteria for MDD

12 months

HDRS ≤ 8

151

• PST-group

•PST-RN

• Antidepressant

• PST+antidepressant

• 24/39

• 23/41

• 20/36

• 23/35

• 62

• 56

• 56

• 66

Schulberg et al., 1998 [38]

DSM-IIIR criteria for MDD

8 months

HDRS ≤ 7

184

• IPT

• Nortriptyline

• 49/93

• 52/91

• 57

• 53

Scott et al., 1992 [39]

DSM-IIIR criteria for MDD

4 months

HDRS ≤ 7

121

• CBT

• Counselling

• Amitriptyline

• Usual care

• 12/30

• 22/30

• 18/31

• 14/30

• 40

• 73

• 58

• 47

Program Interventions

Katon et al.,1999 [40]

Diagnosed as MDD by GP

6 months

Presence of 0 or 1 SCID-assessed symptoms

228

• Collaborative care

• Usual Care

• 50/114

• 35/114

• 44

• 31

Katzelnick et al., 2000 [41]

Diagnosed as MDD by GP and HDRS ≥ 15

12 months

HDRS ≤ 7

407

• Depression management

• Usual care

• 92/218

• 49/189

• 42

• 26

Kutcher et al., 2002 [42]

Diagnosed as MDD by GP

29 weeks

8 weeks or longer with HDRS ≤ 10

269

• Sertraline

• Sertraline + adherence program

• 84/138

• 88/131

• 61

• 67

Rost et al., 2002 [43]

Diagnosed as MDD by GP

24 months

CES-D ≤ 16

211

• Enhanced depression care

• Usual care

• 85/115

• 39/96

• 74

• 41

  1. (Abbreviations: BDI – Beck Depression Inventory, CBT – Cognitive Behavioural Therapy, CES-D – Centre for Epidemiological Studies – Depression Scale, HDRS – Hamilton Depression Rating Scale, HSCL-D-20 – 20-item Hopkins Symptom Check List, IPT-Interpersonal Psychotherapy, MADRS – Montgomery-Asberg Depression Rating Scale, MDD – Major Depressive Disorder, PST – Problem Solving Therapy, PST-PC – Problem Solving Therapy, administered by Primary Care Physician, PST-RN – Problem Solving Therapy, administered by Registered Nurse, RDC – Research Diagnostic Criteria, SCAN – Schedules of Clinical Assessment in Neuropsychiatry, SCID – Structured Clinical Interview for DSM-III-R.)