From: Is remission of depressive symptoms in primary care a realistic goal? A meta-analysis
Study | Diagnostic Criteria | Follow up Period | Remission Criteria | Total N | Intervention | Intervention Remission Rate | Remission % |
---|---|---|---|---|---|---|---|
Psychological Intervention Only | |||||||
Dowrick et al., 2000 [31] | DSM-IV criteria for MDD or Adjustment Disorder | 6 months | No MDD detected by SCAN interview | 425 | • PST • Usual Care •Prevention course | • 58/128 • 76/189 • 44/108 | • 45 • 38 • 41 |
Antidepressant Intervention Only | |||||||
Benkert et al., 2000 [32] | DSM-IV criteria for MDD and HDRS ≥ 18 | 6 weeks | HDRS ≤ 7 | 275 | • Mirtazapine • Paroxetine | • 52/139 • 42/136 | • 37 • 31 |
Patris et al.,1996 [33] | DSM-IIIR criteria for MDD | 8 weeks | MADRS ≤ 12 | 357 | • Citalopram • Fluoxetine | • 114/173 • 110/184 | • 66 • 60 |
Wade et al., 2002 [34] | DSM-IV criteria for MDD | 8 weeks | MADRS ≤ 12 | 380 | • Escitalopram • Placebo | • 92/191 • 64/189 | • 48 • 34 |
Psychological Intervention + Antidepressants | |||||||
Chilvers et al., 2001 [35] | Diagnosed as MDD by GP | 12 months | RDC <4, BDI <10, or clear documentation in GP notes that patient is well | 103 | Randomised only: • Antidepressant • Counselling | • 39/51 • 33/52 | • 76 • 63 |
Mynors-Wallis et al., 1995 [36] | Diagnosed as MDD by GP | 12 weeks | HDRS ≤ 7 or BDI ≤ 8 | 91 | • PST • Amitriptyline • Placebo | • 18/30 • 16/31 • 8/30 | • 60 • 52 • 27 |
Mynors-Wallis et al., 2000 [37] | RDC criteria for MDD | 12 months | HDRS ≤ 8 | 151 | • PST-group •PST-RN • Antidepressant • PST+antidepressant | • 24/39 • 23/41 • 20/36 • 23/35 | • 62 • 56 • 56 • 66 |
Schulberg et al., 1998 [38] | DSM-IIIR criteria for MDD | 8 months | HDRS ≤ 7 | 184 | • IPT • Nortriptyline | • 49/93 • 52/91 | • 57 • 53 |
Scott et al., 1992 [39] | DSM-IIIR criteria for MDD | 4 months | HDRS ≤ 7 | 121 | • CBT • Counselling • Amitriptyline • Usual care | • 12/30 • 22/30 • 18/31 • 14/30 | • 40 • 73 • 58 • 47 |
Program Interventions | |||||||
Katon et al.,1999 [40] | Diagnosed as MDD by GP | 6 months | Presence of 0 or 1 SCID-assessed symptoms | 228 | • Collaborative care • Usual Care | • 50/114 • 35/114 | • 44 • 31 |
Katzelnick et al., 2000 [41] | Diagnosed as MDD by GP and HDRS ≥ 15 | 12 months | HDRS ≤ 7 | 407 | • Depression management • Usual care | • 92/218 • 49/189 | • 42 • 26 |
Kutcher et al., 2002 [42] | Diagnosed as MDD by GP | 29 weeks | 8 weeks or longer with HDRS ≤ 10 | 269 | • Sertraline • Sertraline + adherence program | • 84/138 • 88/131 | • 61 • 67 |
Rost et al., 2002 [43] | Diagnosed as MDD by GP | 24 months | CES-D ≤ 16 | 211 | • Enhanced depression care • Usual care | • 85/115 • 39/96 | • 74 • 41 |