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Table 4 Subgroup analysis of the intervention effect on the percentage of days adherence to prescribed medication

From: An explanatory randomised controlled trial of a nurse-led, consultation-based intervention to support patients with adherence to taking glucose lowering medication for type 2 diabetes

Sub-group variable Sub-group category (L = Low or H = High) N per sub group Intervention arm Standard care arm Intervention- Control (SE)* Difference (H-L) (95% C.I.) P interaction
HbA1c % (mmol/mol) 7.5 – 7.9 (58-63) 85 80.4 (24.5) 62.6 (34.2) 17.7 (6.4)   
  8.0 - 12.4 (64-112) 108 74.8 (27.7) 72.8 (27.8) 2.0 (5.3) -15.8 (-32.9, 1.2) 0.07
Age (years) 37 – 64 94 75.0 (25.61) 72.3 (27.3) 2.7 (5.6)   
  65 and over 100 80.0 (27.1) 66.4 (33.2) 13.5 (6.0) 10.8 (-5.4, 27.2) 0.19
Total number of medications 0 – 5 89 80.2 (23.3) 73.0 (27.0) 7.2 (5.3)   
  6 and over 105 75.1 (28.5) 65 .2 (33.7) 10.0 (6.1) 2.8 (-13.5, 19.1) 0.74
Self reported adherence at baseline 0-23 102 75.0 (26.4) 70.9 (27.2) 4.1 (5.5)   
  24 or 25 70 85.9 (21.3) 68.0 (33.9) 17.9 (6.8) 13.8 (-3.2, 30.0) 0.11
Prior randomisation to medication monitoring device No 102 76.6 (28.7) 71.0 (29.3) 5.6 (5.8)   
  Yes 92 78.2 (23.7) 66.65 (32.6) 11.6 (5.9) 6.0 (-10.5, 22.7) 0.48
Gender Male 127 77.0 (28.3) 66.4 (31.5) 10.6 (5.3)   
  Female 67 78.0 (22.9) 74.8 (28.8) 3.3 (6.4) -7.3 (-24.3, 9.6) 0.39
  1. Effect estimates, confidence intervals and p-values from non-parametric bootstrap percentile method (50,000 replications).
  2. * Estimated intervention effects are positive within each subgroup.